Results 131 to 140 of about 1,647,355 (316)

Supplementary figure 1 from Characterization of Cell-Free DNA Size Distribution in Osteosarcoma Patients

, 2023
Sasimol Udomruk, Areerak Phanphaisarn, Thanat Kanthawang, Apiwat Sangphukieo, Songphon Sutthitthasakul, Siripong Tongjai, Pimpisa Teeyakasem, Patcharawadee Thongkumkoon, Santhasiri Orrapin, Sutpirat Moonmuang, Jeerawan Klangjorhor, Arnat Pasena, Pathacha Suksakit, Sivamoke Dissook, Pitithat Puranachot, Jongkolnee Settakorn, Tonapha Pusadee, Dumnoensun Pruksakorn, Parunya Chaiyawat   +18 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The role of protein kinases in DNA replication in Saccharomyces cerevisiae

, 2010
The initiation of DNA replication at the onset of S phase in eukaryotic cells is a critically important and tightly regulated process. Multiple origins of replication in the genome must be co-ordinately regulated such that duplication of the chromosomes ...
Sweet, S.
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations

, 2010
Mutations of mitochondrial DNA are associated with a wide spectrum of disorders, primarily affecting the central nervous system and muscle function. The specific consequences of mitochondrial DNA mutations for neuronal pathophysiology are not understood.
Turnbull, Douglass M., Turnbull, Doug, Kirby, Denise M., Abramov, Andrey Y., Duchen, Michael, Abramov, Andrey, Smulders-Srinivasan, Tora, Smulders-Srinivasan, Tora K.; id_orcid, Duchen, Michael R., Acin-Perez, Rebecca, Enriquez, José Antonio, Kirby, Denise, Smulders-Srinivasan, Tora K., Lightowlers, Robert, Acin-Perez, Rebeca, Enriquez, Jose, Lightowlers, Robert N.   +16 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

High cell-free DNA is associated with disease progression, inflammasome activation and elevated levels of inflammasome-related cytokine IL-18 in patients with myelofibrosis [PDF]

, 2023
Geraldine De Luca, Paola R. Lev, María Fernanda Camacho, Nora P. Goette, Federico Sackmann, Miguel A. Castro Ríos, Beatriz Moiraghi, Verónica Cortes Guerrieri, Georgina Bendek, Emiliano Carricondo, Alicia Enrico, Verónica Vallejo‐Ruiz, Ana Inés Varela, Marina Khoury, Marina Gutiérrez, Irene Larripa, Rosana F. Marta, Ana C. Glembotsky, Paula G. Heller   +18 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts [PDF]

, 2013
UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in epigenetic regulation through the recognition of various histone marks and interaction with chromatin-modifying proteins.
Taylor, Elaine, Price, Jordan, Bonsu-Dartnall, Nicola, Lindsay, Howard   +3 more
core