Results 141 to 150 of about 1,647,355 (316)

Polyamine Depletion with Two Different Polyamine Analogues Causes DNA Damage in Human Breast Cancer Cell Lines

, 2008
It is well known that the positively charged polyamines have a DNA-stabilizing function and that polyamine depletion alters chromatin function. We have previously shown that polyamine depletion causes an S phase prolongation, and others have shown that ...
Oredsson, Stina,, Johansson, Veronica,, Alm, Kersti,, Lund University.   +3 more
core   +1 more source

Plasma cell-free DNA as predictor of disease status in patients with differentiated thyroid cancer - a prospective study from a tertiary care institution [PDF]

Rashi Goel, Swayamjeet Satapathy, Kunal Ramesh Chandekar, Sanjana Ballal, Shipra Agarwal, Suryanarayan S. V. Deo, Madhavi Tripathi, Chandrasekhar Bal   +7 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Artemis over-expression and radiosensitivity in human cell lines [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The cellular radiosensitivity of two fibroblast cell lines derived from a breast cancer patient that “over-reacted” to radiotherapy (84BR) and a patient ...
Ulus-Senguloglu, Gonul
core  

Extraction of cell-free DNA from urine, using polylysine-coated silica particles

, 2017
Sho Takano, Qingjiang Hu, Takaki Amamoto, Paulo Refinetti, Koshi Mimori, Takashi Funatsu, Masaru Kato   +6 more
openalex   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

, 2015
DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to ...
Aitkenhead, H, Gileadi, Opher, Cooper, Christopher D O, Newman, JA, Cooper, CD, Gileadi, O, Cooper, Christopher D.O., Newman, Joseph A., Aitkenhead, Hazel   +8 more
core   +2 more sources

Cell-free HPV DNA as a complementary biomarker to imaging in HPV-associated oropharyngeal squamous cell carcinoma: a narrative synthesis of key studies [PDF]

Ingeborg Tinhofer, Franziska Hausmann
openalex   +1 more source

Identification of driver genes and somatic mutations in cell‐free DNA of patients with pulmonary lymphangioleiomyomatosis [PDF]

, 2019
Li Zhang, Mingjie Wang, Wei Wang, Jingya Zhao, Jia‐Liang Wu, Yan‐Pu Liu, Hong Zhu, Jieming Qu, Min Zhou   +8 more
openalex   +1 more source

Supplemental Table 1 from Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA

, 2023
Jeffrey C. Thompson, Stephanie S. Yee, Andrea B. Troxel, Samantha L. Savitch, Ryan Fan, David Balli, David Lieberman, Jennifer D. Morrissette, Tracey L. Evans, Joshua Bauml, Charų C. Aggarwal, John A. Kosteva, Evan Alley, Christine Ciunci, Roger B. Cohen, Stephen Bagley, Susan Stonehouse-Lee, Victoria Sherry, Elizabeth R. Gilbert, Corey J. Langer, Anil Vachani, Erica L. Carpenter   +21 more
openalex   +1 more source