Results 211 to 220 of about 1,959,228 (334)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Suite of Biochemical and Cell-Based Assays for the Characterization of Kirsten Rat Sarcoma (KRAS) Inhibitors and Degraders. [PDF]

ACS Pharmacol Transl Sci
Kidane M, Hoffman RM, Wolfe-Demarco JK, Huang TY, Teng CL, Samanta S, Gonzalez Lira LM, Lin-Jones J, Pallares G, Lamerdin JE, Servant NB, Lee CY, Yang CT, Bernatchez JA.   +13 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study. [PDF]

Front Immunol
Goncalves D, Benaiteau M, Rogemond V, Closs S, Pinto AL, Dhairi M, Villard M, Picard G, Fabien N, Honnorat J.   +9 more
europepmc   +1 more source

Cell-Based Assays to Detect Innate Immune Response Modulating Impurities: Application to Biosimilar Insulin [PDF]

Cheng Her, Seth G. Thacker, Joseph Balsamo, Logan K. Baker, Derek D.C. Ireland, Eric Pang, Daniela Verthelyi   +6 more
openalex   +1 more source

2525 Development of human cell-based screening assays to detect subject-specific drug-response variability [PDF]

, 2018
Francesca Stillitano, Joshua Mayourian, Jaydev Dave, Jean‐Sébastien Hulot, Roger J. Hajjar   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Performance of cryptogenic new onset refractory status epilepticus score in a Brazilian cohort after testing for antineuronal antibodies with tissue-based and cell-based assays. [PDF]

Epilepsia
Ferreira JHF, Gomes AM, Zetehaku AC, Marinho TF, Toso FF, Disserol CCD, Krueger MB, Santos MLSF, Juliano AFB, Barbosa TL, de Almeida Rocha LJ, Gameleira FT, Paolilo RB, Daccach V, Gomes JPI, Lin K, da Nóbrega AW, Marmentini EL, Fusão EF, de Cuffa A, Tavares GLA, Dias RM, Diniz SSL, Siquineli F, Braga-Neto P, Nobrega PR, Sanders LP, Carvalho FMM, Pereira RBR, de Melo ES, de Miranda Henriques-Souza AM, de Oliveira Godeiro C, Arambula OG, de Souza E Silva FN, Couto KO, Danieli D, Seitz KW, Dellavance A, Endmayr V, Höftberger R, Andrade LEC, Caboclo LO, Dutra LA.   +42 more
europepmc   +1 more source

Direct and Indirect Antioxidant Effects of Selected Plant Phenolics in Cell-Based Assays. [PDF]

Molecules, 2021
Treml J, Večeřová P, Herczogová P, Šmejkal K.   +3 more
europepmc   +1 more source

Comparison of Different Solid-Phase Cleanup Methods Prior to the Detection of Ciguatoxins in Fish by Cell-Based Assay and LC-MS/MS

Andres Sanchez‐Henao, F. Real, Yefermin Darias-Dágfeel, Natalia García‐Álvarez, Jorge Diogène, Maria Rambla-Alegre   +5 more
openalex   +1 more source