Results 191 to 200 of about 1,590,893 (316)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Impact of immunosuppression drugs on human T cell assays

, 2012
Immune monitoring assays, particularly T cell functional assays, may predict tolerance and rejection post transplantation. However, immunosuppression drugs taken by patients after receiving transplant may be carried over into the assays, which may ...
Mariela Lucia Pauli
core  

In vitro and computational approaches to predict developmental toxicity: Integrating PBPK models with cell-based assays. [PDF]

Toxicol Appl Pharmacol
Moreau M, Antonijevic T, Hall JC, Fisher J.   +3 more
europepmc   +1 more source

Vascular and Blood Compatibility of Engineered Cationic Cellulose Nanocrystals in Cell-Based Assays. [PDF]

Nanomaterials (Basel), 2021
Bernier A, Tobias T, Nguyen H, Kumar S, Tuga B, Imtiaz Y, Smith CW, Sunasee R, Ckless K.   +8 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A Microfluidic Device Integrating a Glucose Sensor and Calibration Function for Cell-Based Assays. [PDF]

Biosensors (Basel)
Chen L, Shinha K, Nakamura H, Komori K, Kimura H.   +4 more
europepmc   +1 more source

Conformation-stabilizing ELISA and cell-based assays reveal patient subgroups targeting three different epitopes of AGO1 antibodies. [PDF]

Front Immunol, 2022
Moritz CP, Do LD, Tholance Y, Vallayer PB, Rogemond V, Joubert B, Ferraud K, La Marca C, Camdessanché JP, Honnorat J, Antoine JC.   +10 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

JCV-specific cell-based assays for PML risk assessment in lupus and multiple sclerosis patients with and without natalizumab. [PDF]

Front Neurol
Wu Q, Mills EA, Wang Q, Mao G, Mao-Draayer Y.   +4 more
europepmc   +1 more source

Phytochemical Profile and Chemopreventive Properties of Cooked Glutinous Purple Rice Extracts Using Cell-Based Assays and Rat Model. [PDF]

Foods, 2022
Guo H, Chariyakornkul A, Phannasorn W, Mahatheeranont S, Wongpoomchai R.   +4 more
europepmc   +1 more source