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In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models
SLAS Discovery, 2023 Three-dimensional (3D) cell culture technology has been steadily studied since the 1990's due to its superior biocompatibility compared to the conventional two-dimensional (2D) cell culture technology, and has recently developed into an organoid culture ...
Dong Woo Lee, Sang-Yun Lee
exaly +2 more sources
International Journal of Molecular Sciences, 2021 The process of evaluating the efficacy and toxicity of drugs is important in the production of new drugs to treat diseases. Testing in humans is the most accurate method, but there are technical and ethical limitations.
Sun-Woong Kang +2 more
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Is It Time to Start Transitioning From 2D to 3D Cell Culture?
Frontiers in Molecular Biosciences, 2020 Cell culture is an important and necessary process in drug discovery, cancer research, as well as stem cell study. Most cells are currently cultured using two-dimensional (2D) methods but new and improved methods that implement three-dimensional (3D ...
Caleb Jensen, Teng Yong
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Animal‐cell culture media: History, characteristics, and current issues
Reproductive Medicine and Biology, 2017 Cell culture technology has spread prolifically within a century, a variety of culture media has been designed. This review goes through the history, characteristics and current issues of animal‐cell culture media.
Tatsuma Yao, Yuta Asayama
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Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages [PDF]
BioImpacts, 2021 Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue.
Reddy Amala, Sundaresan Sujatha
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mAbs, 2023 Introns are included in genes encoding therapeutic proteins for their well-documented function of boosting expression. However, mis-splicing of introns in recombinant immunoglobulin (IgG) heavy chain (HC) transcripts can produce amino acid sequence ...
Emma Kelsall +5 more
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3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages
International Journal of Molecular Sciences, 2021 The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long been used in cancer research. However, this system cannot be fully translated into clinical trials to ideally represent physiological conditions.
O. Habanjar +3 more
semanticscholar +1 more source
Cancers, 2021 Simple Summary Three-dimensional (3D) cell culture models have been proposed as alternatives for initial drug screening to increase drug development efficiency.
Mélanie A. G. Barbosa +4 more
semanticscholar +1 more source
Gene Expression and Immunochemistry Analysis of ADAMTS-1 and Versican in Ameloblastoma
International Journal of Dentistry, 2022 Background. Ameloblastoma is a benign but locally invasive odontogenic epithelial tumor, associated with a high recurrence rate after treatment. The action of enzymes of the metalloproteinase family is important to the degraded extracellular matrix ...
Osvaldo Rodrigues de Souza Neto +4 more
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Molluscan cells in culture: primary cell cultures and cell lines [PDF]
Canadian Journal of Zoology, 2013 In vitro cell culture systems from molluscs have significantly contributed to our basic understanding of complex physiological processes occurring within or between tissue-specific cells, yielding information unattainable using intact animal models.
T P, Yoshino, U, Bickham, C J, Bayne
openaire +2 more sources