Results 221 to 230 of about 1,959,228 (334)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Skin-Whitening, Antiwrinkle, and Moisturizing Effects of <i>Astilboides tabularis</i> (Hemsl.) Engl. Root Extracts in Cell-Based Assays and Three-Dimensional Artificial Skin Models. [PDF]

Int J Mol Sci
Yoo NH, Lee HS, Park SM, Baek YS, Kim MJ.   +4 more
europepmc   +1 more source

New Modalities of 3D Pluripotent Stem Cell-Based Assays in Cardiovascular Toxicity. [PDF]

Front Pharmacol, 2021
Orsolits B, Kovács Z, Kriston-Vizi J, Merkely B, Földes G.   +4 more
europepmc   +1 more source

Cell‐Compatible Hydrogels: A Microfluidic Hydrogel Capable of Cell Preservation without Perfusion Culture under Cell‐Based Assay Conditions (Adv. Mater. 28/2010) [PDF]

, 2010
Yan Xu, Kae Sato, Kazuma Mawatari, Tomohiro Konno, Kihoon Jang, Kazuhíko Ishihara, Takehiko Kitamori   +6 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Evaluation of the Antioxidant Properties and Bioactivity of Koroneiki and Athinolia Olive Varieties Using In Vitro Cell-Free and Cell-Based Assays. [PDF]

Int J Mol Sci
Gkasdrogka M, Tekos F, Skaperda Z, Vardakas P, Kouretas D.   +4 more
europepmc   +1 more source

Discovery of diminazene as a dual inhibitor of SARS-CoV-2 human host proteases TMPRSS2 and furin using cell-based assays. [PDF]

Curr Res Chem Biol, 2022
Xu YM, Inacio MC, Liu MX, Gunatilaka AAL.   +3 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Chemical and Biological Characterization of Metabolites from Silene viridiflora Using Mass Spectrometric and Cell-Based Assays. [PDF]

Biomolecules
Mamadalieva NZ, Koval A, Dusmuratov MM, Hussain H, Katanaev VL.   +4 more
europepmc   +1 more source

Simplifying marine biotoxin data analysis: Advancing the Neuro-2a cell-based assay using R

Synne T. Frøstrup, Christian Ritz, Oliver Kappenstein, Astrid Spielmeyer, Christopher R. Loeffler   +4 more
openalex   +1 more source