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Label-Free Cell-Based Functional Assays
Combinatorial Chemistry & High Throughput Screening, 2008Label-free technologies based on electrical impedance or refractive index are new tools for measuring a cell-based functional response. Although the technologies are relatively new to high throughput screening cell-based applications, they are rapidly generating interest in that they are able to measure a phenotypic response using cells natively ...
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Cell-based assays for kinase drug discovery
Drug Discovery Today: Technologies, 2010Kinases are important therapeutic targets. Potent in vitro inhibitors are readily produced, but these compounds are not always potent in cells. Because cell potency is crucial for efficacy, cell-based assays are important for successful inhibitor development. In this review kinase cell assays are divided into four types.
Gary K. Smith, Edgar R. Wood
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Cell-based assays on microfluidic chips
2023In view of miniaturization, different microfluidic devices have been designed and developed to overcome the difficulties of conventional cell-based assays in terms of throughput, single-cell isolation, cost, and flexibility. These platforms are advantageous because of their low reagent consumption, small amount of sample required, as well as facile ...
Hosseini, Motaharesadat +2 more
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Cell-Based Assays for High-Throughput Screening
Molecular Biotechnology, 2010Cell-based assays represent approximately half of all high-throughput screens currently performed. Here, we review in brief the history and status of high-throughput screening (HTS), and summarize some of the challenges and benefits associated with the use of cell-based assays in HTS.
W Frank, An, Nicola, Tolliday
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2017
Tumor necrosis factor alpha (TNFa) not only plays a key role in the human immune system, but also has a cytotoxic effect on tumor cells. Owing to this function, TNFa can become a considerable candidate for chemotherapy but needs to be delivered locally.
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Tumor necrosis factor alpha (TNFa) not only plays a key role in the human immune system, but also has a cytotoxic effect on tumor cells. Owing to this function, TNFa can become a considerable candidate for chemotherapy but needs to be delivered locally.
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Microchips for Cell-Based Assays
2009Analysis of cells is a cornerstone in biomedical research. Traditional methods for cell culture and tissue analysis can be replaced by various microchips as discussed in this chapter. A tissue array is an example of microchip that provides higher throughput of tissue analysis.
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Cell-based assay for β-secretase activity
Analytical Biochemistry, 2003The cerebral deposition of amyloid beta-peptide (Abeta) is a major factor in the etiology of Alzheimer's disease. beta-Secretase (BACE) initiates the generation of Abeta by cleaving the amyloid precursor protein at the beta-site and is therefore a prime target for therapeutic intervention. Here we report a cell-based method suitable for monitoring BACE
Myungsok, Oh +6 more
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Microarray Platforms for Enzymatic and Cell‐Based Assays
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Juan J, Díaz-Mochón +2 more
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Analyzing Trophoblast Function Using Cell-Based Assays
2017Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation,
Katie L, Powell, Anthony W, Ashton
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Contact hypersensitivity: T-cell based assay
Current Opinion in Toxicology, 2017Abstract To develop an in vitro assay that recapitulates the key event of Allergic Contact Dermatitis (ACD), that is the priming of human effector T cells by hapten-presenting dendritic cells (DCs), and then allows for the sensitive detection of chemical allergens, represents a highly desirable goal but also a major challenge.
Marc Vocanson +7 more
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