Results 181 to 190 of about 121,085,656 (267)

Overview of clear cell renal cell carcinoma: from mechanisms to clinical. [PDF]

Front Med (Lausanne)
Yang H, Zhang X, Ji Q, Sheng X.
europepmc   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes

Type 2 diabetes (T2D) is a devastating chronic disease marked by pancreatic b-cell dysfunction and insulin resistance, whose pathophysiology remains poorly understood.
Rorsman, Patrik, Heyn, Holger, Balboa, Diego, Moratinos, Sonia, Groen, Nathalie, Bernardo, Edgar, Torrens-Dinarès, Miquel, van Oudenaarden, Alexander, De Vas, Matías Gonzalo, Planas-Fèlix, Mercè, de Koning, Eelco, Vernia, Santiago, Bonàs-Guarch, Sílvia, García-Hurtado, Javier, Cuenca-Ardura, Mirabai, Mollandin, Fanny, Eils, Roland, Conrad, Christian, Maestro, Miguel Angel, Ferrer, Jorge, Ravassard, Philippe, Dou, Haiqiang   +21 more
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Crosstalk Between mTOR and NF-κB Signaling Pathways in Clear Cell Renal Cell Carcinoma. [PDF]

Int J Mol Sci
Glueck M, Lucaciu A, Inukollu S, Kesavan R, Janssen A, Pfeilschifter J, Subburayalu J, Krishnan RK, Vutukuri R.   +8 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Spontaneous Regression of Clear Cell Renal Cell Carcinoma Metastases or Immune Restoration? [PDF]

Curr Oncol
Vacheret C, Moinard-Butot F, Reberol L, Ciccolini A, Cazzato RL, Barthélémy P.   +5 more
europepmc   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Nuclear PML expression as a prognostic biomarker in localised clear cell renal cell carcinoma. [PDF]

BJUI Compass
Kosola S, Laajala TD, Payne I, Kukkula A, Luomala L, Mirtti T, Mattila K, Vainio P, Sundvall M, Jaakkola PM.   +9 more
europepmc   +1 more source