Results 191 to 200 of about 20,525,491 (347)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Science, 2009
M. V. Vander Heiden, L. Cantley, C. Thompson   +2 more
semanticscholar   +1 more source

THE SIGNIFICANCE OF THE EPITHELIAL CELLS AND SAPROPHYTES IN SPUTUM [PDF]

, 1917
M Otani
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Bioinformatic Analysis and Molecular Docking Identify Isorhamnetin Is a Candidate Compound in the Treatment of Pulmonary Artery Hypertension. [PDF]

Anatol J Cardiol
Shao C, Xia W, Liu Y.
europepmc   +1 more source

Apoptosis: A Review of Programmed Cell Death

Toxicologic pathology (Print), 2007
S. Elmore
semanticscholar   +1 more source

Comparative Rates of Division in Large and Small Cells of Developing Fruits [PDF]

, 1942
Edmund W. Sinnott
openalex   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches. [PDF]

Neuropsychopharmacol Rep
Rajabi M, Shafaeibajestan S, Asadpour S, Alyari G, Taei N, Kohkalani M, Raoufinia R, Afarande H, Saburi E.   +8 more
europepmc   +1 more source

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Science, 2016
I. Tirosh, B. Izar, S. Prakadan, M. Wadsworth, D. Treacy, John J. Trombetta, Asaf Rotem, Christopher Rodman, C. Lian, G. Murphy, M. Fallahi-Sichani, K. Dutton-Regester, Jia-Ren Lin, Ofir Cohen, Parin Shah, Diana Lu, Alex S Genshaft, T. Hughes, Carly G. K. Ziegler, S. Kazer, A. Gaillard, Kellie E. Kolb, A. Villani, Cory M. Johannessen, A. Andreev, E. V. Van Allen, M. Bertagnolli, P. Sorger, R. Sullivan, K. Flaherty, Dennie T. Frederick, Judit Jané-Valbuena, Charles H. Yoon, O. Rozenblatt-Rosen, A. Shalek, A. Regev, L. Garraway   +36 more
semanticscholar   +1 more source