Results 201 to 210 of about 19,797,384 (359)

Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction [PDF]

, 2016
Man J. Livingston, Han‐Fei Ding, Shuang Huang, Joseph A. Hill, Xiao-Ming Yin, Zheng Dong   +5 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Spatiotemporal Production of Reactive Oxygen Species by NADPH Oxidase Is Critical for Tapetal Programmed Cell Death and Pollen Development in Arabidopsis

, 2014
Hongtao Xie, Zhi‐Yuan Wan, Sha Li, Yan Zhang   +3 more
openalex   +1 more source

Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria [PDF]

, 1996
K. Kawagoe, Daisuke Kitamura, Masaru Okabe, Ichiro Taniuchi, Masahito Ikawa, Takeshi Watanabe, Taroh Kinoshita, Junji Takeda   +7 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Allogeneic Mesenchymal Stem Cells Stimulate Cartilage Regeneration and Are Safe for Single-Stage Cartilage Repair in Humans upon Mixture with Recycled Autologous Chondrons [PDF]

, 2016
Tommy S. de Windt, Luciënne A. Vonk, Ineke Slaper‐Cortenbach, Marcel P. H. van den Broek, Razmara Nizak, Mattie H.P. van Rijen, Roel A. de Weger, Wouter J.A. Dhert, Daniël B.F. Saris   +8 more
openalex   +1 more source

Forecasting of COVID-19 using deep layer Recurrent Neural Networks (RNNs) with Gated Recurrent Units (GRUs) and Long Short-Term Memory (LSTM) cells

, 2021
K.E. ArunKumar, Dinesh V. Kalaga, Ch. Mohan Sai Kumar, Masahiro Kawaji, Timothy M. Brenza   +4 more
openalex   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Fifty Years of Natural Killer Cells: Milestones and Future Horizons. [PDF]

Scand J Immunol
Lundqvist A, Wagner AK, Chambers BJ, Dahlberg CIM, Sundbäck J, Cuapio A, Alici E, Ljunggren HG.   +7 more
europepmc   +1 more source

Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents

, 2006
Tao Sun, Simon J. Jackson, John W. Haycock, Sheila MacNeil   +3 more
openalex   +2 more sources