Results 231 to 240 of about 19,797,384 (359)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

High-throughput single-cell DNA methylation and chromatin accessibility co-profiling with SpliCOOL-seq. [PDF]

Clin Transl Med
Shen Q, Deng E, Luo L, Zhang J, Yang Q, Su D, Fan X.   +6 more
europepmc   +1 more source

Regulation of Cell Proliferation by a Morphogen Gradient [PDF]

, 2005
Dragana Rogulja, Kenneth D. Irvine
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury. [PDF]

Liver Int
Zhou X, Shao S, Yang D, Cheng Z, Tanaka T, Leung PSC, Tsuneyama K, Ansari AA, Ridgway WM, Invernizzi P, Bowlus CL, Gershwin ME, Zhang W.   +12 more
europepmc   +1 more source

Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells [PDF]

, 2017
Nils-Petter Rudqvist, Karsten A. Pilones, Claire Lhuillier, Erik Wennerberg, John-William Sidhom, Ryan Emerson, Harlan Robins, Jonathan P. Schneck, Silvia C. Formenti, Sandra Demaria   +9 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways [PDF]

, 2018
Ying Yang, Paul Riccio, Michael Schotsaert, Munemasa Mori, Jining Lü, Dong-Kee Lee, Adolfo Garcı́a-Sastre, Jianming Xu, Wellington V. Cardoso   +8 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Cell-Type-specific Regulation of Nerve Growth Factor (NGF) Synthesis in Non-neuronal Cells [PDF]

, 1991
Matsuoka, Ichiro, Meyer, Michael, Thoenen, Hans   +2 more
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