Results 71 to 80 of about 10,262,815 (318)

The Diversification of Cell Death and Immunity: Memento Mori.

, 2019
Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and
Legrand, AJ, Konstantinou, M, Goode, EF, Meier, P   +3 more
core   +1 more source

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

, 2020
Deregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive.
Jiang, Jue, Han, Meng, Wang, Yanwu, Zhang, Yingchi, Feng, Hui, Zhu, Xiaofan, Qing, Guoliang, Sun, Yonghua, Wu, Chao, Yue, Ming, Cai, Xiaolian, Jiang, Peng, Wang, Tianci, Li, Peng, Liu, Hudan, Su, Hexiu, Wang, Jingchao, Xiao, Wuhan   +17 more
core   +1 more source

Cell Simulation as Cell Segmentation

Nature Methods
Abstract Single-cell spatial transcriptomics promises a highly detailed view of a cell’s transcriptional state and microenvironment, yet inaccurate cell segmentation can render this data murky by misattributing large numbers of transcripts to nearby cells or conjuring nonexistent cells. We adopt methods from ab initio cell simulation to
Daniel C. Jones, Anna E. Elz, Azadeh Hadadianpour, Heeju Ryu, David R. Glass, Evan W. Newell   +5 more
openaire   +3 more sources

Cell Docking, Movement and Cell-Cell Interactions of Heterogeneous Cell Suspensions in a Cell Manipulation Microdevice [PDF]

Sensors, 2011
This study demonstrates a novel cell manipulation microdevice for cell docking, culturing, cell-cell contact and interaction by microfluidic manipulation of heterogeneous cell suspensions. Heterogeneous cell suspensions include disparate blood cells of natural killer cells and leukemia cancer cells for immune cell transplantation therapy.
Fei-Lung Lai, Yu-Hung Wang, Yu-Wei Chung, Shiaw-Min Hwang, Long-Sun Huang   +4 more
openaire   +3 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Scaffold-Free Bioprinter Utilizing Layer-By-Layer Printing of Cellular Spheroids

Micromachines, 2019
Free from the limitations posed by exogenous scaffolds or extracellular matrix-based materials, scaffold-free engineered tissues have immense clinical potential.
Wesley LaBarge, Andrés Morales, Daniëlle Pretorius, Asher M. Kahn-Krell, Ramaswamy Kannappan, Jianyi Zhang   +5 more
doaj   +1 more source

Effects of the Laplace pressure on the cells during cytokinesis

iScience, 2021
Summary: The Laplace pressure is one of the most fundamental regulators that determine cell shape and function, and thus has been receiving widespread attention.
Xiaohuan Wang, Long Li, Yingfeng Shao, Jiachen Wei, Ruopu Song, Songjie Zheng, Yuqiao Li, Fan Song   +7 more
doaj   +1 more source

PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny [PDF]

, 2022
Hematopoietic stem cell (HSC) generation in the aorta-gonad-mesonephros region requiresHSC specification signals from the surrounding microenvironment. In zebrafish, PDGFB/PDGFRβ signaling controls hematopoietic stem/progenitor cell (HSPC) generation and
Telma Ventura, van de Werken, Harmen Jan George, Crisan, Mihaela, Sá da Bandeira, Diana, Henar Cuervo, Ventura, Telma, van IJcken, Wilfred F J, Matthieu Vermeren, Jung, Bongnam, Betsholtz, Christer, van Ijcken, Wilfred F.J., Gonzalez , Zaniah Nashira, van de Werken, Harmen Jan George; id_orcid, Beltran, Mariana, Neil Cowan Henderson, da Bandeira, Diana Sa, Madalena Marques, Zaniah Nashira Gonzalez, Wilfred F.J. van Ijcken, Vermeren, Matthieu; id_orcid, Harmen Jan George van de Werken, Gonzalez, Zaniah Nashira, Mariana Beltran, Vink, Chris Sebastiaan, Cuervo, Henar, Marques, Madalena, Stefancova, Dorota, Bongnam Jung, Kilpatrick, Alastair Morris; id_orcid, Forbes, Stuart John, Mihaela Crisan, Diana Sá da Bandeira, Christer Betsholtz, Van Der Linden, Reinier, van Ijcken, Wilfred F.J.; id_orcid, Alastair Morris Kilpatrick, Fiona Rossi, van Ijcken, Wilfred F. J., Kilpatrick, Alastair Morris, Stuart John Forbes, Henderson, Neil Cowan, Gomez-Salazar, Mario, Mario Gomez-Salazar, Chris Sebastiaan Vink, Dorota Stefancova, Reinier van der Linden, Rossi, Fiona, Vermeren, Matthieu   +47 more
core   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity

, 2019
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J, Ask, Eivind Heggernes, Goodridge, Jodie, Lorenz, S, Lorenz, Susanne, Goodridge, JP, Clancy, T, Malmberg, Karl-Johan, Pfefferle, A,, Sohlberg, Ebba, Sohlberg, E,, Jacobs, Benedikt Marcel, Netskar, Herman, Netskar, H, Ask, EH, Pfefferle, Aline, Clancy, Trevor, Jacobs, B   +17 more
core   +1 more source