Results 71 to 80 of about 11,485,087 (317)

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila [PDF]

, 2022
Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show
Southall, Tony D., Tang, Alexander M, Jones, D. Leanne, Stack, Brian J, Brand, Andrea H., Sandall, Sharsti L., Sênos Demarco, Rafael, Southall, Tony D, Jones, D Leanne, Tang, Alexander M., Stack, Brian J., Voog, Justin, Sandall, Sharsti L, Brand, Andrea H, Demarco, Rafael Senos   +14 more
core   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source

The Diversification of Cell Death and Immunity: Memento Mori.

, 2019
Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell death pathways have adapted and
Legrand, AJ, Konstantinou, M, Goode, EF, Meier, P   +3 more
core   +1 more source

PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny [PDF]

, 2022
Hematopoietic stem cell (HSC) generation in the aorta-gonad-mesonephros region requiresHSC specification signals from the surrounding microenvironment. In zebrafish, PDGFB/PDGFRβ signaling controls hematopoietic stem/progenitor cell (HSPC) generation and
Telma Ventura, van de Werken, Harmen Jan George, Crisan, Mihaela, Sá da Bandeira, Diana, Henar Cuervo, Ventura, Telma, van IJcken, Wilfred F J, Matthieu Vermeren, Jung, Bongnam, Betsholtz, Christer, van Ijcken, Wilfred F.J., Gonzalez , Zaniah Nashira, van de Werken, Harmen Jan George; id_orcid, Beltran, Mariana, Neil Cowan Henderson, da Bandeira, Diana Sa, Madalena Marques, Zaniah Nashira Gonzalez, Wilfred F.J. van Ijcken, Vermeren, Matthieu; id_orcid, Harmen Jan George van de Werken, Gonzalez, Zaniah Nashira, Mariana Beltran, Vink, Chris Sebastiaan, Cuervo, Henar, Marques, Madalena, Stefancova, Dorota, Bongnam Jung, Kilpatrick, Alastair Morris; id_orcid, Forbes, Stuart John, Mihaela Crisan, Diana Sá da Bandeira, Christer Betsholtz, Van Der Linden, Reinier, van Ijcken, Wilfred F.J.; id_orcid, Alastair Morris Kilpatrick, Fiona Rossi, van Ijcken, Wilfred F. J., Kilpatrick, Alastair Morris, Stuart John Forbes, Henderson, Neil Cowan, Gomez-Salazar, Mario, Mario Gomez-Salazar, Chris Sebastiaan Vink, Dorota Stefancova, Reinier van der Linden, Rossi, Fiona, Vermeren, Matthieu   +47 more
core   +2 more sources

Scaffold-Free Bioprinter Utilizing Layer-By-Layer Printing of Cellular Spheroids

Micromachines, 2019
Free from the limitations posed by exogenous scaffolds or extracellular matrix-based materials, scaffold-free engineered tissues have immense clinical potential.
Wesley LaBarge, Andrés Morales, Daniëlle Pretorius, Asher M. Kahn-Krell, Ramaswamy Kannappan, Jianyi Zhang   +5 more
doaj   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

Cell Simulation as Cell Segmentation

Nature Methods
Abstract Single-cell spatial transcriptomics promises a highly detailed view of a cell’s transcriptional state and microenvironment, yet inaccurate cell segmentation can render this data murky by misattributing large numbers of transcripts to nearby cells or conjuring nonexistent cells. We adopt methods from ab initio cell simulation to
Daniel C. Jones, Anna E. Elz, Azadeh Hadadianpour, Heeju Ryu, David R. Glass, Evan W. Newell   +5 more
openaire   +3 more sources

Vinculin in cell–cell and cell–matrix adhesions [PDF]

Cellular and Molecular Life Sciences, 2017
Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions.
Jennifer L. Bays, Kris A. DeMali
openaire   +2 more sources

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source