Results 71 to 80 of about 11,901,652 (317)

Hematopoietic stem cell responsiveness to exogenous signals is limited by Caspase-3

, 2008
SummaryLimited responsiveness to inflammatory cytokines is a feature of adult hematopoietic stem cells and contributes to the relative quiescence and durability of the stem cell population in vivo.
Riese, Matthew J, Woo, Minna, Karlsson, Göran, Milne, Craig D, Lo Celso, Cristina, Karlsson, Göran,, Scadden, David T, Fleming, Heather E, Paige, Christopher J, Karlsson, Stefan, Janzen, Viktor, Reynolds, Griffin, Karlsson, Stefan,, Riedt, Tamara, Lund University.   +14 more
core   +1 more source

Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila [PDF]

, 2022
Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show
Southall, Tony D., Tang, Alexander M, Jones, D. Leanne, Stack, Brian J, Brand, Andrea H., Sandall, Sharsti L., Sênos Demarco, Rafael, Southall, Tony D, Jones, D Leanne, Tang, Alexander M., Stack, Brian J., Voog, Justin, Sandall, Sharsti L, Brand, Andrea H, Demarco, Rafael Senos, Justin Voog, D. Leanne Jones, Brian J. Stack, Tony D. Southall, Alexander M. Tang, Rafael Sênos Demarco, Andrea H. Brand, Sharsti L. Sandall   +22 more
core   +1 more source

Scaffold-Free Bioprinter Utilizing Layer-By-Layer Printing of Cellular Spheroids

Micromachines, 2019
Free from the limitations posed by exogenous scaffolds or extracellular matrix-based materials, scaffold-free engineered tissues have immense clinical potential.
Wesley LaBarge, Andrés Morales, Daniëlle Pretorius, Asher M. Kahn-Krell, Ramaswamy Kannappan, Jianyi Zhang   +5 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Cell Simulation as Cell Segmentation

Nature Methods
Abstract Single-cell spatial transcriptomics promises a highly detailed view of a cell’s transcriptional state and microenvironment, yet inaccurate cell segmentation can render this data murky by misattributing large numbers of transcripts to nearby cells or conjuring nonexistent cells. We adopt methods from ab initio cell simulation to
Daniel C. Jones, Anna E. Elz, Azadeh Hadadianpour, Heeju Ryu, David R. Glass, Evan W. Newell   +5 more
openaire   +3 more sources

Vinculin in cell–cell and cell–matrix adhesions [PDF]

Cellular and Molecular Life Sciences, 2017
Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions.
Jennifer L. Bays, Kris A. DeMali
openaire   +2 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Why is it taking so long to develop clinically competitive stem cell therapies for CNS disorders?

, 2012
The remarkable advancements in basic stem cell research with implications for several central nervous system disorders have so far not been translated into clinically effective therapies.
Lindvall, Olle, Lindvall, Olle,, Lund University.   +2 more
core   +1 more source

A microfluidic-based lid device for conventional cell culture dishes to automatically control oxygen level

BioTechniques, 2018
Most conventional hypoxic cell culture systems undergo reoxygenation during experimental manipulations, resulting in undesirable effects including the reduction of cell viability.
Seung Yeob Lee, Sung Yang
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source