Results 81 to 90 of about 11,901,652 (317)

Balancing Expectations for Success in Stem Cell-Based Clinical Trials for Parkinson's Disease

, 2020
Upcoming clinical trials assessing transplantation of stem cell-derived dopaminergic neurons into the striatum in patients with Parkinson's disease could generate groundbreaking results on neuronal replacement in the human brain.
Lindvall, Olle, Lindvall, Olle,, Lund University.   +2 more
core   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

, 2011
SummarySomatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age.
Sigvardsson, Mikael,, Norddahl, Gudmundur L,, Wahlestedt, Martin, Sigvardsson, Mikael, Gudmundur L. Norddahl, Sten, Gerd, Mikael Sigvardsson, Pronk, Kees-Jan, Martin Wahlestedt, Cornelis J. Pronk, Norddahl, Gudmundur, Norddahl, Gudmundur L.,, Wahlestedt, Martin,, David Bryder, Nygren, Jens, Sten, Gerd,, Bryder, David,, Ugale, Amol, Pronk, Cornelis J,, Nygren, Jens M,, Jens M. Nygren, Bryder, David, Amol Ugale, Pronk, Cornelis J.,, Nygren, Jens M.,, Ugale, Amol,, Gerd Sten, Pronk, Kees-Jan,, Norddahl, Gudmundur,, Nygren, Jens,, Lund University.   +30 more
core   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

\(S\)-cells are cells

Bulletin of the Polish Academy of Sciences. Mathematics, 1995
Attention -- the reader should begin with Lect. Notes Math. 1524, 316-322 (1992; Zbl 0779.32006), a paper by \textit{K. Kurdyka}, to become familiar with the \(s\)-cells he introduced. An \(S\)-cell is a closure of an \(s\)-cell and its precise definition is given as Definition 1.
Kwieciński, Michał, Artur Piękosz
openaire   +1 more source

Immune status of patients with acne and concomitant skin malasseziosis

Patologìâ, 2013
Introduction: Acne is the most common skin disease that affects up to 85% of people between 12 and 25 years old and 11% of persons over the age of 25 years.
E. Yu. Koretskaya
doaj   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome

, 2015
Thousands of cis-elements in genomes are predicted to have vital functions. Although conservation, activity in surrogate assays, polymorphisms, and disease mutations provide functional clues, deletion from endogenous loci constitutes the gold-standard ...
Rajendran Sanalkumar, Jin Soo Kim, Chandler Zuo, Yoon-A Kang, Sunduz Keles, Prithvia Devadas, Duk Hyoung Kim, Emery H. Bresnick, Kyle J. Hewitt, Rajalekshmi Prathibha, Kirby D Johnson, Colin N. Dewey, Hewitt, Kyle J., Sanalkumar, Rajendran, Prathibha, Rajalekshmi, Kim, Duk Hyoung, Kang, Yoon-A., Dewey, Colin N., Johnson, Kirby D., Devadas, Prithvia, Kim, Jin-Soo, Bresnick, Emery H., Keles, Sunduz, Zuo, Chandler   +23 more
core   +1 more source

Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides

, 2020
The bacterial cell wall is made of peptidoglycan (PG), a polymer that is essential for the maintenance of cell shape and survival. During growth, bacteria remodel their PG, releasing fragments that are predominantly reinternalized and recycled.
Dorr, Tobias, Cava, Felipe, Hernandez, Sara B.,, Waldor, Matthew K., Hernandez, Sara B., Cava, Felipe,   +5 more
core   +1 more source