Results 101 to 110 of about 11,485,087 (317)

tRNA methylation resolves codon usage bias at the limit of cell viability.

, 2022
Codon usage of each genome is closely correlated with the abundance of tRNA isoacceptors. How codon usage bias is resolved by tRNA post-transcriptional modifications is largely unknown. Here we demonstrate that the N1-methylation of guanosine at position
Hou, Ya-Ming, Nakano, Yuko, Christian, Thomas, Masuda, Isao, Moore, Henry, Matsubara, Ryuma, Lowe, Todd M, Frenkel-Morgenstern, Milana, Yamaki, Yuka, Maharjan, Sunita, Detroja, Rajesh, Tagore, Somnath   +11 more
core   +1 more source

Intracellular vacuoles induced by hypo-osmotic stress visualized by coherent anti-Stokes Raman scattering (CARS) spectroscopic imaging

Applied Physics Express
We analyzed the effects of a hypo-osmotic environment on rat Schwann cells, a type of glial cell surrounding neurons, using ultra-broadband multiplex coherent anti-Stokes Raman scattering (CARS) microscopy.
Zuliang Hu, Kyota Shirane, Kota Aramaki, Philippe Leproux, Akihito Inoko, Hideaki Kano, Ayami Matsushima   +6 more
doaj   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Autocrine glutamate signaling drives cell competition in Drosophila.

Cell competition is an evolutionarily conserved quality control process that eliminates suboptimal or potentially dangerous cells. Although differential metabolic states act as direct drivers of competition, how these are measured across tissues is not ...
Soares, CC, Maresma, MF, Rizzo, A, Meier, P   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease

, 2020
Dopaminergic neurons (DAns), generated from human pluripotent stem cells (hPSCs), are capable of functionally integrating following transplantation and have recently advanced to clinical trials for Parkinson's disease (PD).
Kirik, Deniz,, Kirik, Deniz, Thompson, Lachlan H., Penna, Vanessa,, Hunt, Cameron P.J., de Luzy, Isabelle R.,, Hunt, Cameron P.J.,, Kauhausen, Jessica A., Gantner, Carlos W.,, Bye, Christopher R.,, Thompson, Lachlan H.,, Niclis, Jonathan C.,, Niclis, Jonathan C., Ermine, Charlotte M., Moriarty, Niamh, Bye, Christopher R., Gantner, Carlos W., de Luzy, Isabelle R., Penna, Vanessa, Parish, Clare L., Kauhausen, Jessica A.,, Parish, Clare L.,, Pouton, Colin W., Moriarty, Niamh,, Lund University., Pouton, Colin W.,, Ermine, Charlotte M.,   +26 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mechanosensitive Hair Cell-Like Cells from Embryonic and Induced Pluripotent Stem Cells

, 2018
Mechanosensitive sensory hair cells are the linchpin of our senses of hearing and balance. The inability of the mammalian inner ear to regenerate lost hair cells is the major reason for the permanence of hearing loss and certain balance disorders.
Peng, AW, Diensthuber, M, Heller, S, Ricci, AJ, Oshima, K, Shin, K   +5 more
core   +1 more source