Results 111 to 120 of about 11,485,087 (317)

The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin [PDF]

, 2004
Copyright © 2004 by The American Society for Cell Biology.Ubiquitylation is a necessary step in the endocytosis and lysosomal trafficking of many plasma membrane proteins and can also influence protein trafficking in the biosynthetic pathway.
Murray, Rachael, Murray, RZ, Wood, S., Wood, SA, Wood, Stephen J., Jolly, LA, A. Jolly, Lachlan, A. Wood, Stephen, Jolly, Lachlan, Murray, R., Jolly, L., Z. Murray, Rachael   +11 more
core   +2 more sources

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas

, 2021
Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ductal cells contribute to the β ...
Rackham, Chloe, Lambert, C, Evans, Ian, Sancho, Rocio; id_orcid, Messal, Hendrik A., Jones, P, Hubber, Ella-louise, Messal, HA, Lambert, Christopher, Behrens, Axel, Heimberg, Harry, Hubber, E-L, Heimberg, H, Rackham, C, Jones, Peter; id_orcid, Evans, I, Gribben, C, Behrens, A, Gribben, Christopher, Sancho, R   +19 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Environmentally dependent and independent control of 3D cell shape.

How cancer cells determine their shape in response to three-dimensional (3D) geometric and mechanical cues is unclear. We develop an approach to quantify the 3D cell shape of over 60,000 melanoma cells in collagen hydrogels using high-throughput stage ...
Dent, LG, Rowe-Brown, L, Maioli, V, Sparks, H, Munro, I, Arias-Garcia, M, Bakal, C, Butera, F, Bousgouni, V, Kumar, S, Dunsby, C, Curry, N, Jones, I   +12 more
core   +1 more source

Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction.

, 2017
Heparan sulfate proteoglycans (HSPGs) critically modulate adhesion-, growth-, and migration-related processes. Here, we show that the transmembrane protein, Nogo-A, inhibits neurite outgrowth and cell spreading in neurons and Nogo-A-responsive cell lines
Buffo, Annalisa, Kempf, Anissa, Schmandke, Andre, Pertz, Olivier, Boda, Enrica, Tews, Bjoern, Kaelin, Andrea M, Grande, Valentina, Schwab, Martin E, Kwok, Jessica C F, Fritz, Rafael, Schmandke, Antonio, Ristic, Zorica, Fawcett, James W   +13 more
core   +1 more source

Position Statement: Minimal Criteria for Reporting Veterinary and Animal Medicine Research for Mesenchymal Stromal/Stem Cells in Orthopedic Applications

Frontiers in Veterinary Science, 2022
Debbie J. Guest, Jayesh Dudhia, Roger K. W. Smith, Scott J. Roberts, Michael Conzemius, John F. Innes, Lisa A. Fortier, Richard L. Meeson   +7 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Deciphering Membrane Proteins Through Deep Learning Models by Revealing Their Locale Within the Cell

Bioengineering
Membrane proteins constitute essential biomolecules attached to or integrated into cellular and organelle membranes, playing diverse roles in cellular processes. Their precise localization is crucial for understanding their functions.
Mehwish Faiz, Saad Jawaid Khan, Fahad Azim, Nazia Ejaz, Fahad Shamim   +4 more
doaj   +1 more source

Representação visual de estruturas biológicas em materiais de ensino Visual representation of biological structures in teaching material

História, Ciências, Saúde: Manguinhos, 1998
Este trabalho foi motivado pela necessidade de se definir parâmetros de apresentação e tratamento da informação científica em materiais de ensino. Através de consultas a bibliotecas e a especialistas em ciências da saúde e artes gráficas e visuais, fez ...
Marina Azevedo Morato, Miriam Struchiner, Eduardo Bordoni, Regina Maria Vieira Ricciardi   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source