Results 131 to 140 of about 11,901,652 (317)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A cell is a cell is a cell

, 2008
Es wurden Erklärverhalten und Einschätzung von Laienwissen durch Experten für die medizinische Emailberatung untersucht. Hierbei wurden die Tutoringforschung sowie psycholinguistische Ansätze berücksichtigt. Eingangs wurde das Wissen einer Laienstichprobe (Studie I, n = 100) per Fragebogen untersucht.
openaire  

Optical Tweezers in Human Cancers

Zhongliu Fangzhi Yanjiu
Optical tweezers are a means to manipulate objects with light. Optical tweezers can obtain a nanometer space, piconewton force, and a millisecond resolution; thus, they are excellently suited for studying biological processes from the single-cell to the ...
ZHANG Baihong, YUE Hongyun
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

, 2013
SummaryDefining the metabolic programs that underlie stem cell maintenance will be essential for developing strategies to manipulate stem cell capacity.
Soga, Tomoyoshi, Ikeda, Eiji, Rahimi, Yasmeen, Nagamatsu, G, Ikeda, E, Kobayashi, Hiroshi, Goda, N, Johnson, RS, Nakamura-Ishizu, Ayako, Suda, Toshio, Takubo, Keiyo, Soga, T, Nakamura-Ishizu, A, Nagamatsu, Go, Goda, Nobuhito, Takubo, K, 池田, 栄二, Kobayashi, CI, Hirao, Atsushi, Kobayashi, H, Rahimi, Y, Suematsu, Makoto, Kobayashi, Chiharu I., Johnson, Randall S.   +23 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

MAP4K4 inhibition promotes survival of human stem cell-derived cardiomyocytes and reduces infarct size in vivo

, 2019
[[abstract]]Heart disease is a paramount cause of global death and disability. Although cardiomyocyte death plays a causal role and its suppression would be logical, no clinical counter-measures target the responsible intracellular pathways.
Fiedler, LR;Chapman, K;Xie, M;Maifoshie, E;Jenkins, M;Golforoush, PA;Bellahcene, M;Noseda, M;Faust, D;Jarvis, A;Newton, G;Paiva, MA;Harada, M;Stuckey, DJ;Song, W;Habib, J;Narasimham, P;Aqil, R;Sanmugalingam, D;Yan, R;Pavanello, L;Sano, M;Wang, SC;Sampson, RD;Kanayaganam, S;Taffet, GE;Michael, LH;Entman, ML;Tan, TH;Harding, SE;Low, CMR;Tralau-Stewart, C;Perrior, T;Schneider, MD
core   +1 more source

Small cell prostate cancer: risks for metastatic disease

Frontiers in Urology
ObjectiveTo identify clinical and demographic factors associated with the presence and distribution of metastatic disease at diagnosis in patients with small cell carcinoma of the prostate (SCCP).IntroductionSmall cell carcinoma of the prostate is a rare
Essam Al-Snayyan, Jamil Qiqieh, Cameron Peres, Sharon Tan, Susan Lyons, Avery Mendelson   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source