Results 131 to 140 of about 11,485,087 (317)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

A cell is a cell is a cell

open access: yes, 2008
Es wurden Erklärverhalten und Einschätzung von Laienwissen durch Experten für die medizinische Emailberatung untersucht. Hierbei wurden die Tutoringforschung sowie psycholinguistische Ansätze berücksichtigt. Eingangs wurde das Wissen einer Laienstichprobe (Studie I, n = 100) per Fragebogen untersucht.
openaire  

RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming

open access: yes, 2019
Incomplete knowledge of the mechanisms at work continues to hamper efforts to maximize reprogramming efficiency. Here, we present a systematic genome-wide RNAi screen to determine the global regulators during the early stages of human reprogramming.
Guo, Hong Chao   +19 more
core   +1 more source

Optical Tweezers in Human Cancers

open access: yesZhongliu Fangzhi Yanjiu
Optical tweezers are a means to manipulate objects with light. Optical tweezers can obtain a nanometer space, piconewton force, and a millisecond resolution; thus, they are excellently suited for studying biological processes from the single-cell to the ...
ZHANG Baihong, YUE Hongyun
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision.

open access: yes
Reactive oxygen species (ROS) influence cell proliferation and fate decisions by oxidizing cysteine residues (S-sulfenylation) of proteins, but specific targets and underlying regulatory mechanisms remain poorly defined.
Coupe, D   +10 more
core   +1 more source

Small cell prostate cancer: risks for metastatic disease

open access: yesFrontiers in Urology
ObjectiveTo identify clinical and demographic factors associated with the presence and distribution of metastatic disease at diagnosis in patients with small cell carcinoma of the prostate (SCCP).IntroductionSmall cell carcinoma of the prostate is a rare
Essam Al-Snayyan   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Home - About - Disclaimer - Privacy