Results 41 to 50 of about 583,703 (360)

Intercellular adhesion molecule-4 and CD36 are implicated in the abnormal adhesiveness of sickle cell SAD mouse erythrocytes to endothelium

Haematologica, 2010
Background Abnormal adhesiveness of red blood cells to endothelium has been implicated in vaso-occlusive crisis of sickle cell disease. The present study examined whether the SAD mouse model exhibits the same abnormalities of red blood cell adhesion as ...
Marie-Marcelle Trinh-Trang-Tan, Camilo Vilela-Lamego, Julien Picot, Marie-Paule Wautier, Jean-Pierre Cartron   +4 more
doaj   +1 more source

EpCAM as Modulator of Tissue Plasticity

Cells, 2020
The Epithelial Cell Adhesion Molecule or EpCAM is a well-known marker highly expressed in carcinomas and showing a strong correlation with poor cancer prognosis.
François Fagotto
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Novel roles of the chemorepellent axon guidance molecule RGMa in cell migration and adhesion [PDF]

, 2012
The repulsive guidance molecule A (RGMa) is a contact-mediated axon guidance molecule that has significant roles in central nervous system (CNS) development.
Aamar E, Babitt JL, Bork P, Brinks H, Camus LM, Cha JY, Colombatti A, Connor RM, Conrad S, Cooke JE, Cousin H, Feys T, Gavert N, Gessert S, Goodeve AC, Goto T, Halbrooks PJ, Karaulanov EE, Kee N, Keller R, Keller R, Keller R, Kidd T, Kondo Y, Kwan KM, Lamb TM, Laurent A, Li J, Li VSW, Louie SH, Matsunaga E, Mawdsley DJ, Millard SS, Mirakaj V, Monnier PP, Muramatsu R, Niederkofler V, Nieuwkoop P, Okamura Y, Oldekamp J, Popsueva AE, Rajagopalan S, Re'em-Kalma Y, Samad TA, Samad TA, Schafer MK, Schmidtmer J, Shiau CE, Shin GJ, Skoglund P, Tardif S, Tassew NG, Tassew NG, Vielmetter J, Wilson NH, Wilson NH, Wojtowicz WM, Xia Y, Zhou Z   +58 more
core   +1 more source

Correlating single-molecule rupture mechanics with cell population adhesion by yeast display

Biophysical Reports, 2022
Here, we present a method based on yeast surface display that allows for direct comparison between population-level cell adhesion strength and single-molecule receptor-ligand rupture mechanics. We developed a high-throughput yeast adhesion assay in which
Mariana Sá Santos, Haipei Liu, Valentin Schittny, Rosario Vanella, Michael A. Nash   +4 more
doaj  

Association of endothelin-1 and cell surface adhesion molecules levels in patients with systemic sclerosis

Journal of Laboratory Medicine, 2020
Endothelin-1 (ET-1) has been implicated in the pathogenesis of inflammatory and fibrotic diseases, including systemic sclerosis. In addition to modulating vascular tone and extracellular matrix turnover, ET-1 up-regulates cell surface adhesion molecules ...
Mauliūtė Monika, Rugienė Rita, Žėkas Vytautas, Bagdonaitė Loreta   +3 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways [PDF]

, 2014
The terpenoid 17-O-acetylacuminolide (AA) was shown to inhibit the production of several inflammatory mediators. However, the mechanisms by which this compound elicited its anti-inflammatory activity remain to be elucidated.
Achoui, Mouna, Haegeman, Guy, Heyninck, Karen, Looi, Chung Yeng, Mustafa, Ali Mohd, Mustafa, Mohd Rais   +5 more
core   +1 more source

Protocadherin-1 is expressed in the notochord of mouse embryo but is dispensable for its formation

Biochemistry and Biophysics Reports, 2021
Notochord is an embryonic midline structure that serves as mechanical support for axis elongation and the signaling center for the surrounding tissues.
Kanako Fukunaga, Masafumi Tanji, Nana Hanzawa, Hiroki Kuroda, Masafumi Inui   +4 more
doaj  

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source