Results 51 to 60 of about 1,169,770 (361)

Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells

International Journal of Nanomedicine, 2014
Lei Li,1,* Dongxi Xiang,2,* Sarah Shigdar,2 Wenrong Yang,3 Qiong Li,2 Jia Lin,4 Kexin Liu,1 Wei Duan2 1College of Pharmacy, Dalian Medical University, Dalian, People's Republic of China; 2School of Medicine, Faculty of Health, Deakin University ...
Li L, Xiang DX, Shigdar S, Yang WR, Li Q, Lin J, Liu KX, Duan W   +7 more
doaj  

Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion

Cellular and Molecular Life Sciences
Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive ...
Klaus Ebnet, Michel Aurrand-Lions
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria

BMC Molecular and Cell Biology, 2020
Background Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a recently identified cell adhesion molecule which is predominantly expressed by epithelial cells of the intestine and the kidney. Its expression is downregulated in both
Christian Hartmann, Ysabel Alessa Schwietzer, Daniel Kummer, Nils Kirschnick, Esther Hoppe, Eva-Maria Thüring, Mark Glaesner-Ebnet, Frauke Brinkmann, Volker Gerke, Stefan Reuter, Masanori Nakayama, Klaus Ebnet   +11 more
doaj   +1 more source

Nephrin phosphorylation regulates podocyte adhesion through the PINCH-1-ILK-α-parvin complex [PDF]

BMB Reports, 2013
Nephrin, a structural molecule, is also a signaling molecule afterphosphorylation. Inhibition of nephrin phosphorylation iscorrelated with podocyte injury.
Dongqing Zha, Cheng Chen, Wei Liang, Xinghua Chen, Tean Ma, Hongxia Yang, Harry van Goor, Guohua Ding   +7 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

IL-17A induces endothelial inflammation in systemic sclerosis via the ERK signaling pathway. [PDF]

PLoS ONE, 2013
Recent reports have demonstrated that endothelial cells are involved in vascular inflammatory injury in systemic sclerosis (SSc) and interleukin-17A (IL-17A) plays a crucial role in the pathogenesis of SSC.
Xiaojing Xing, Ji Yang, Xiaoqin Yang, Yi Wei, Lubing Zhu, Di Gao, Ming Li   +6 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Expression changes of nerve cell adhesion molecules L1 and semaphorin 3A after peripheral nerve injury

Neural Regeneration Research, 2016
The expression of nerve cell adhesion molecule L1 in the neuronal growth cone of the central nervous system is strongly associated with the direction of growth of the axon, but its role in the regeneration of the peripheral nerve is still unknown.
Qian-ru He, Meng Cong, Qing-zhong Chen, Ya-feng Sheng, Jian Li, Qi Zhang, Fei Ding, Yan-pei Gong   +7 more
doaj   +1 more source