Results 61 to 70 of about 574,774 (360)

Epithelial cell-adhesion molecule-directed trifunctional antibody immunotherapy for symptom management of advanced ovarian cancer

Clinical Pharmacology: Advances and Applications, 2013
Ramez N Eskander, Krishnansu S Tewari Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Irvine, CA, USA Abstract: Despite advances in cytotoxic chemotherapy and surgical cytoreduction, disease recurrence
Eskander RN, Tewari KS
doaj  

Nephrin phosphorylation regulates podocyte adhesion through the PINCH-1-ILK-α-parvin complex [PDF]

BMB Reports, 2013
Nephrin, a structural molecule, is also a signaling molecule afterphosphorylation. Inhibition of nephrin phosphorylation iscorrelated with podocyte injury.
Dongqing Zha, Cheng Chen, Wei Liang, Xinghua Chen, Tean Ma, Hongxia Yang, Harry van Goor, Guohua Ding   +7 more
doaj   +1 more source

L-selectin and beta(2)-integrin expression on circulating bovine polymorphonuclear leukocytes during endotoxin mastitis [PDF]

, 2003
The aim of this in vivo study was to examine the effect of intramammarily administered endotoxin (lipopolysaccharide, LPS) on the expression of L-selectin (CD62L) and the beta(2)-integrin subunits CD11b and CD18 on circulating bovine PMN.
Burvenich, Christian, Diez Fraile, Araceli, Duchateau, Luc, Meyer, Evelyne   +3 more
core  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells

International Journal of Nanomedicine, 2014
Lei Li,1,* Dongxi Xiang,2,* Sarah Shigdar,2 Wenrong Yang,3 Qiong Li,2 Jia Lin,4 Kexin Liu,1 Wei Duan2 1College of Pharmacy, Dalian Medical University, Dalian, People's Republic of China; 2School of Medicine, Faculty of Health, Deakin University ...
Li L, Xiang DX, Shigdar S, Yang WR, Li Q, Lin J, Liu KX, Duan W   +7 more
doaj  

Novel roles of the chemorepellent axon guidance molecule RGMa in cell migration and adhesion [PDF]

, 2012
The repulsive guidance molecule A (RGMa) is a contact-mediated axon guidance molecule that has significant roles in central nervous system (CNS) development.
Aamar E, Babitt JL, Bork P, Brinks H, Camus LM, Cha JY, Colombatti A, Connor RM, Conrad S, Cooke JE, Cousin H, Feys T, Gavert N, Gessert S, Goodeve AC, Goto T, Halbrooks PJ, Karaulanov EE, Kee N, Keller R, Keller R, Keller R, Kidd T, Kondo Y, Kwan KM, Lamb TM, Laurent A, Li J, Li VSW, Louie SH, Matsunaga E, Mawdsley DJ, Millard SS, Mirakaj V, Monnier PP, Muramatsu R, Niederkofler V, Nieuwkoop P, Okamura Y, Oldekamp J, Popsueva AE, Rajagopalan S, Re'em-Kalma Y, Samad TA, Samad TA, Schafer MK, Schmidtmer J, Shiau CE, Shin GJ, Skoglund P, Tardif S, Tassew NG, Tassew NG, Vielmetter J, Wilson NH, Wilson NH, Wojtowicz WM, Xia Y, Zhou Z   +58 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

The Art of Mast Cell Adhesion

Cells, 2020
Cell adhesion is one of the basic phenomena occurring in a living organism, affecting many other processes such as proliferation, differentiation, migration, or cell viability.
Joanna Pastwińska, Paulina Żelechowska, Aurelia Walczak-Drzewiecka, Ewa Brzezińska-Błaszczyk, Jarosław Dastych   +4 more
doaj   +1 more source

Adhesion Molecule Expression in Polymorphic Light Eruption [PDF]

, 1992
Endothelial leukocyte adhesion molecule-1 (ELAM-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) are cytokine-regulated cell-surface Ieukocyte adhesion molecules. We have investigated the in vivo kinetics and
Allen, Michael H, Barker, Jonathan N W N, Haskard, Dorian O, Hawk, John L M, Leiferman, Kristin M, MacDonald, Donald M, Norris, Paul G   +6 more
core   +1 more source