Results 81 to 90 of about 574,774 (360)

IL-17A induces endothelial inflammation in systemic sclerosis via the ERK signaling pathway. [PDF]

PLoS ONE, 2013
Recent reports have demonstrated that endothelial cells are involved in vascular inflammatory injury in systemic sclerosis (SSc) and interleukin-17A (IL-17A) plays a crucial role in the pathogenesis of SSC.
Xiaojing Xing, Ji Yang, Xiaoqin Yang, Yi Wei, Lubing Zhu, Di Gao, Ming Li   +6 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The Interplay between Chemistry and Mechanics in the Transduction of a Mechanical Signal into a Biochemical Function [PDF]

, 2007
There are many processes in biology in which mechanical forces are generated. Force-bearing networks can transduce locally developed mechanical signals very extensively over different parts of the cell or tissues.
Ainavarapu, Alon, Altmann, Baker, Barakat, Barsegov, Becker, Bell, Best, Best, Bhasin, Braun, Brockwell, Brooks, Brooks, Bruno Samorì, Bryant, Bustamante, Bustanji, Bustanji, Cao, Carl, Carrion-Vazquez, Carson, Chang, Chtcheglova, Cieplak, Cluzel, De Keulenaer, De Los Rios, Dembo, Dettmann, Dietz, Discher, Doggett, Doggett, Dudko, Ericson, Evans, Evans, Evans, Evans, Evans, Evans, Fantner, Fantner, Fenouillet, Fernandez, Finger, Fisher, Fisher, Fowler, Francesco Valle, Fritz, Gao, Grandi, Guo, Heslot, Higgins, Hotchkiss, Hsiai, Hummer, Hyeon, Jackson, Jiang, Julien, Kawakami, Kellermayer, Kozuka, Kung, Lambert-Vidmar, Lawler, Lawrence, Lay, Lee, Lenne, Li, Li, Li, Li, Li, Li, Lincoln, Liphardt, Liphardt, Lou, Lou, Makarov, Marshall, Marszalek, Massimo Sandal, Matouschek, Matthias, Merkel, Mohamed, Morrow, Neupert, Oberhauser, Oberhauser, Pereverzev, Prajapati, Prakash, Qin, Rief, Rief, Rief, Rief, Ritort, Rouzina, Rubartelli, Rubenstein, Samori, Samori, Sandal, Sarasa-Renedo, Sarkar, Sato, Schnepel, Schulze, Schwaiger, Sengupta, Shimaoka, Smith, Smith, Smith, Smith, Stathakis, Stetefeld, Terada, Thirumalai, Thomas, Thomas, Thompson, Viani, Vladescu, Vogel, Vogel, Vologodskii, Waite, Welsh, West, Wiita, Wilcox, Williams, Xie, Xie, Yago, Yan, Yersin, Yoshimori, Yuan, Zhu, Ziegler   +152 more
core   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

Molecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens, Anouk Mentink, Frank A. W. Coumans, Eshwari Dathathri, Khrystany T. Isebia, Jaco Kraan, Ronald de Wit, John W. M. Martens, Leon W. M. M. Terstappen   +8 more
wiley   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Hypoxia and reoxygenation do not upregulate adhesion molecules and natural killer cell adhesion on human endothelial cells in vitro [PDF]

, 2017
Objectives: Ischemia/reperfusion injury is characterized by endothelial cell activation leading to increased expression of adhesion molecules such as inter-cellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, endothelial- and ...
Maurus, Christine F., Schmidt, Dörthe, Schneider, Mårten K.J., Seebach, Jörg D., Turina, Marko I., Zünd, Gregor   +5 more
core  

Effects of different leukocyte subpopulations and flow conditions on leukocyte accumulation during reperfusion [PDF]

, 2012
Background/Aims: The study examined the interdependent effects of shear stress and different leukocyte subpopulations on endothelial cell activation and cell interactions during low flow and reperfusion.
Haeberle, H.A. (Helene), Johannes, T. (Tanja), Kampmann, M., Nohé, B. (Boris), Ploppa, A. (Annette)   +4 more
core   +2 more sources

The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

Nature Communications, 2016
Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens ...
Yvonne L. Dorland, Tsveta S. Malinova, Anne-Marieke D. van Stalborch, Adam G. Grieve, Daphne van Geemen, Nicolette S. Jansen, Bart-Jan de Kreuk, Kalim Nawaz, Jeroen Kole, Dirk Geerts, René J. P. Musters, Johan de Rooij, Peter L. Hordijk, Stephan Huveneers   +13 more
doaj   +1 more source

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]

, 2007
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Adamson, Barreiro, Barreiro, Butcher, Carman, Carman, Carson, Celli, Christine Rampon, Cicmil, Doulet, Durieu-Trautmann, Engelhardt, Etienne, Etienne, Etienne-Manneville, Federici, Gopalakrishnan, Graesser, Gratzinger, Greenwood, Greenwood, Henshall, Hoffmann, Ilan, Jackson, Jean-Pierre Couty, John Greenwood, Kontaridis, Lacalle, Marie-Pierre Laran-Chich, Masuda, Mathilde Leveque, Millan, Muller, Newman, Newman, Patil, Pierre-Olivier Couraud, Pluskota, Reid, Rivard, Roux, Sander, Sandrine Bourdoulous, Schenkel, Schoenwaelder, Schweitzer, Shaw, Viegas, Walters, Wang, Yang, Yang   +53 more
core   +2 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source