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Cell adhesion molecules and cancer

Current Opinion in Oncology, 1992
Cell adhesion molecules are complex protein and carbohydrate molecules of many different types found on the surfaces of all cells. They are important in many aspects of cell biology including development, differentiation, and motility. These processes are frequently disturbed in cancer and recent work has demonstrated that disturbances in cell adhesion
Jonathan Fawcett, Adrian L. Harris
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Glycosyltransferases as cell adhesion molecules

Current Opinion in Cell Biology, 1993
Specific glycosyltransferases are believed to be present on the cell surface, where they may function as cell adhesion molecules by binding oligosaccharide substrates on adjacent cell surfaces or in the extracellular matrix. The best studied of these is beta 1,4-galactosyltransferase, which mediates sperm binding to the egg coat and selected cell ...
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Cell Adhesion Molecules

2019
To orchestrate development and maintain tissue homeostasis, multicellular organisms have evolved a large number of cell adhesion molecules (CAMs). There are four major classes of CAMs: the immunoglobulin superfamily (IgSF), the cadherins, the integrins and the selectins.
Xia-Jing Tong, Yan Zou
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Synaptic Cell Adhesion Molecules

2012
During development of the nervous system following axon pathfinding, synaptic connections are established between neurons. Specific cell adhesion molecules (CAMs) accumulate at pre- and postsynaptic sites and trigger synaptic differentiation through interactions with intra- and extracellular scaffolds. These interactions are important to align pre- and
Olena Bukalo, Alexander Dityatev
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Adhesion molecules in cell interactions

Current Opinion in Immunology, 1993
During a successful immune response, several families of adhesion molecules participate in a cascade of binding events that lead to the binding of leukocytes, both to each other and to cell types such as the endothelium and epithelium. A central theme emerging from recent studies is that the function of an adhesion receptor cannot be inferred from its ...
R. Clive Landis, Nancy Hogg
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Epithelial cell adhesion molecules

Experimental Cell Research, 1986
Recognition and binding between cells are of fundamental importance for a proper function of multicellular organisms, both during embryonic development and in the adult stage. Recently several cell surface proteins that are involved in these phenomena have been discovered.
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Cell Adhesion Molecules and Endometriosis

Seminars in Reproductive Medicine, 2003
The pathogenesis of endometriosis remains poorly defined. The interaction of endometrium with peritoneum is an important aspect of the disease process. Cell adhesion molecules (CAMs) are transmembrane receptors that facilitate intercellular binding and cellular interaction with the extracellular matrix (ECM).
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Cell adhesion molecules as morphoregulators

Current Opinion in Cell Biology, 1995
Many significant advances have been made recently in our understanding of the structure and function of cell adhesion molecules (CAMs). The most provocative, however, are those that indicate that CAM-mediated adhesion may lead to changes in gene expression and those that suggest that the expression of CAM genes may be regulated by the products of Hox ...
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3 Drosophila Cell Adhesion Molecules

1993
Publisher Summary This chapter describes Drosophila cell adhesion molecules. The primary reason for the interest in Drosophila cell adhesion proteins is the ability to undertake sophisticated genetic analyses of function in situ. Analysis in situ is especially important when examining the function during development, where cell culture systems are of
Thomas A. Bunch, Danny L. Brower
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Lectins as cell adhesion molecules

Current Biology, 1992
Abstract Within the past year, there have been major adbances in understanding the structure and function of the selectins, a family of calcium-dependent carbohydrate-binding transmembrane glycoproteins of intermediate molecular size (90–140 kD), and more modest but significant progress has been made for the S-lectins, a family of calcium-independent
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