Results 151 to 160 of about 1,710,556 (364)

Human iPSC-derived neural stem cells engraft and improve pathophysiology of MPS I mice

Molecular Therapy: Methods & Clinical Development
Mucopolysaccharidosis type I (MPS I) is a metabolic disorder characterized by a deficiency in α-l-iduronidase (IDUA), leading to impaired glycosaminoglycan degradation.
Caitlin C. Calhoun, Shih-Hsin Kan, Alexander E. Stover, Jerry F. Harb, Edwin S. Monuki, Raymond Y. Wang, Philip H. Schwartz   +6 more
doaj   +1 more source

Bioengineered tissue and cell therapy products are efficiently cryopreserved with pathogen-inactivated human platelet lysate-based solutions [PDF]

, 2023
María Martín-López, Cristina Rosell‐Valle, Blanca Arribas-Arribas, Beatriz Fernández‐Muñoz, Rosario Jiménez, Sonia Nogueras, Ana Belén García-Delgado, Fernando Campos, Mónica Santos‐González   +8 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Revolutionizing cross professional collaboration outcomes in TBI: emerging trends in diagnostics, personalized medicine, technological innovations and neurorehabilitation

Brain Informatics
Traumatic brain injury (TBI) is still considered a major cause of morbidity and mortality worldwide, and its prevalence is increasing daily. TBI patients are facing difficult diagnostic, management, and rehabilitative challenges.
Mubin Mustafa Kiyani, Shahid Bashir, Benish Shahzadi, Hamid Khan, Maisra Azhar Butt, Syed Ali Hussain, Turki Abualait   +6 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Cell Therapy Based on Adipose Tissue-Derived Stromal Cells Promotes Physiological and Pathological Wound Healing [PDF]

, 2009
Téni G. Ebrahimian, Frédéric Pouzoulet, Claire Squiban, V. Buard, M. André, Béatrice Cousin, P. Gourmelon, Marc Benderitter, Louis Casteilla, Radia Tamarat   +9 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Corrigendum: Regulatory Framework for Advanced Therapy Medicinal Products in Europe and United States

Frontiers in Pharmacology, 2020
Carolina Iglesias-Lopez, Antonia Agustí, Antonia Agustí, Mercè Obach, Antonio Vallano, Antonio Vallano   +5 more
doaj   +1 more source

Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy

Materials Today Bio
Stem cell-based therapy has emerged as a promising approach for heart repair, potentially regenerating damaged heart tissue and improving outcomes for patients with heart disease.
Chuanfeng An, Yuan Zhao, Lipeng Guo, Zhijian Zhang, Chunxiao Yan, Shiying Zhang, Yujie Zhang, Fei Shao, Yuanyuan Qi, Xun wang, Huanan Wang, Lijun Zhang   +11 more
doaj   +1 more source

Recent Advances of Adipose-Tissue-Derived Mesenchymal Stem Cell-Based Therapy for Retinal Diseases [PDF]

, 2023
Lucia Finocchio, Marco Zeppieri, Andrea Gabai, Leopoldo Spadea, Carlo Salati   +4 more
openalex   +1 more source