Results 221 to 230 of about 1,710,556 (364)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Patient-derived tumor organoids: advances, applications, and future directions in biomedical research. [PDF]

Front Med (Lausanne)
Acar A.
europepmc   +1 more source

Induction therapy of tissue regeneration based on tissue engineering Hybrid cell-gene therapy for tissue regeneration

, 2005
Noritoshi Nagaya
openalex   +2 more sources

Application of marine collagen for stem‑cell‑based therapy and tissue regeneration (Review)

, 2021
Chao Liu
openalex   +2 more sources

Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives

Cell Transplantation, 2014
Xiaoting Liang, Yue Ding, Yuelin Zhang, H. Tse, Q. Lian   +4 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Advances in the research and application of stem cell therapies for idiopathic pulmonary fibrosis. [PDF]

Am J Clin Exp Immunol
Xu L, Hou X, Zhou X, Jiang M.
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Advancements in mesenchymal stem cell therapy for chronic wounds: challenges, innovations, and future directions. [PDF]

Front Cell Dev Biol
Tang Y, Su T, Huang B, Xu Q, Chen Q, Zhang S, Li W.   +6 more
europepmc   +1 more source

Cell-Based Gene Therapies and Stem Cells for Regeneration of Ischemic Tissues

, 2011
Rosalinda Madonna, Raffaele De
openalex   +2 more sources