Results 111 to 120 of about 5,639,145 (346)

Throwing Treg cells off balance [PDF]

Nature Reviews Cancer, 2019
Di Pilato et al. selectively modulated the function of regulatory T (Treg) cells in tumours by targeting the CARMA1–BCL10–MALT1 (CBM) signalosome complex in only a fraction of Treg cells and showed that this was sufficient to impede tumour growth and prime the tumour microenvironment for immune checkpoint blockade.
openaire   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Recent and Ancient Signature of Balancing Selection around the S-Locus in Arabidopsis halleri and A. lyrata [PDF]

, 2013
Balancing selection can maintain different alleles over long evolutionary times. Beyond this direct effect on the molecular targets of selection, balancing selection is also expected to increase neutral polymorphism in linked genome regions, in inverse ...
Ruggiero, Maria-Valeria, Roux, Camille, Pauwels, M., Roux, Clément, Castric, Vincent, Vekemans, X., Pauwels, Maxime, M.-V., Ruggiero, Charlesworth, D., Vekemans, Xavier, Charlesworth, Deborah   +10 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Lipid balance and chemoresistance in cancer cells

eLife
A shift in the balance between two lipids – cholesterol and sphingomyelin – makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.
Kaori Kanemaru, Yoshikazu Nakamura
openaire   +3 more sources

Balancing selection and its effects on sequences in nearby genome regions. [PDF]

, 2006
Our understanding of balancing selection is currently becoming greatly clarified by new sequence data being gathered from genes in which polymorphisms are known to be maintained by selection.
Deborah Charlesworth, Charlesworth Deborah, Charlesworth, Deborah   +2 more
core   +2 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Design of optimized single-switch capacitor cell balancing for EV battery management

Results in Engineering
Electric vehicles are at the forefront of the transition towards more sustainable transportation, and battery management systems are tasked with ensuring optimal operation and balancing of the individual cells within a battery pack for increased ...
Anjan N. Padmasali, Savitha G. Kini, Arun P. Parameswaran   +2 more
doaj   +1 more source

State-of-Charge Balancing Control for ON/OFF-Line Internal Cells Using Hybrid Modular Multi-Level Converter and Parallel Modular Dual L-Bridge in a Grid-Scale Battery Energy Storage System

IEEE Access, 2019
Cell state-of-charge (SoC) balancing within a battery energy-storage system (BESS) is the key to optimizing capacity utilization of a BESS. Many cell SoC balancing strategies have been proposed; however, control complexity and slow SoC convergence remain
Ashraf Bani Ahmad, Chia Ai Ooi, Dahaman Ishak, Jiashen Teh   +3 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source