Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology. [PDF]
Rambaldi A+5 more
europepmc +1 more source
Cell biology of viruses that assemble along the biosynthetic pathway
Gareth Griffiths, Peter J. M. Rottier
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Endothelial Cell Injury in Cardiovascular Surgery: The Systemic Inflammatory Response11Recent discoveries in the field of vascular biology have led to an expanded understanding of the pathogenesis of many of the immediate and long-term complications of patients undergoing cardiovascular operations and interventional cardiologic procedures. In particular, the vascular endothelium has emerged as the central focus of many of the biologic events that affect the preoperative, operative, and … [PDF]
Edward M. Boyle+3 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp+13 more
wiley +1 more source
PIWI proteins and piRNAs: key regulators of stem cell biology. [PDF]
Claro-Linares F, Rojas-Ríos P.
europepmc +1 more source
Biology of Human Umbilical Cord Blood‐Derived Hematopoietic Stem/Progenitor Cells [PDF]
Héctor Mayani, Peter M. Lansdorp
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C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald+18 more
wiley +1 more source
Emerging concepts in the molecular cell biology and functions of mammalian erythrocytes. [PDF]
Kumar SD+3 more
europepmc +1 more source