Results 1 to 10 of about 765,092 (159)

A nonautophagic role of ATG5 in regulating cell growth by targeting c-Myc for proteasome-mediated degradation

iScience, 2021
Summary: Autophagy is a conserved biological process that maintains cell homeostasis by targeting macromolecules for lysosome-mediated degradation. The levels of autophagy are relatively lower under normal conditions than under stress conditions (e.g ...
Sheng Li, Leilei Zhang, Guoan Zhang, Guoqiang Shangguan, Xitan Hou, Wanglin Duan, Yan Xi, Nan Xu, Bowen Zhang, Junli Dong, Yequan Wang, Wen Cui, Su Chen   +12 more
doaj   +3 more sources

Early satellite cell communication creates a permissive environment for long-term muscle growth

iScience, 2021
Summary: Using in vivo muscle stem cell (satellite cell)-specific extracellular vesicle (EV) tracking, satellite cell depletion, in vitro cell culture, and single-cell RNA sequencing, we show satellite cells communicate with other cells in skeletal ...
Kevin A. Murach, Bailey D. Peck, Robert A. Policastro, Ivan J. Vechetti, Douglas W. Van Pelt, Cory M. Dungan, Lance T. Denes, Xu Fu, Camille R. Brightwell, Gabriel E. Zentner, Esther E. Dupont-Versteegden, Christopher I. Richards, Jeramiah J. Smith, Christopher S. Fry, John J. McCarthy, Charlotte A. Peterson   +15 more
doaj   +3 more sources

Electrically synchronizing and modulating the dynamics of ERK activation to regulate cell fate

iScience, 2021
Summary: Intracellular signaling dynamics play fundamental roles in cell biology. Precise modulation of the amplitude, duration, and frequency of signaling activation will be a powerful approach to investigate molecular mechanisms as well as to engineer ...
Liang Guo, Kan Zhu, Michael Pargett, Adam Contreras, Patrick Tsai, Quan Qing, Wolfgang Losert, John Albeck, Min Zhao   +8 more
doaj   +3 more sources

Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology

iScience, 2020
Summary: During collective cell migration, front cells tend to extend a predominant leading protrusion, which is rarely present in cells at the side or rear positions.
Heng Wang, Xuan Guo, Xianping Wang, Xiaobo Wang, Jiong Chen   +4 more
doaj   +3 more sources

Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets

iScience, 2022
Summary: The accumulation of lipid droplets (LDs) in the liver is a hallmark of steatosis, which is often associated with lysosomal dysfunction. Nevertheless, the underlying mechanisms remain unclear.
Pei Xuan Song, Juan Peng, Mohyeddine Omrane, Ting ting Cai, Didier Samuel, Ama Gassama-Diagne   +5 more
doaj   +1 more source

Constitutive activation of S1P receptors at the trans-Golgi network is required for surface transport carrier formation

iScience, 2021
Summary: The importance of the G-protein βγ subunits in the regulation of cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PM) is well accepted; however, the molecular mechanism underlying the G-protein activation at the TGN ...
Taro Okada, Susumu Nishida, Lifang Zhang, Nesma Nabil Ibrahim Mohamed, Tianyou Wang, Takeshi Ijuin, Taketoshi Kajimoto, Shun-Ichi Nakamura   +7 more
doaj   +1 more source

Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms

iScience, 2021
Summary: Turnover of the primary cilium (PC) is critical for proliferation and tissue homeostasis. Each key component of the PC resorption machinery, the HEF1/Aurora kinase A (AurA)/HDAC6 pathway harbors cis-elements potentially targeted by the ...
Pam Speight, Matthew Rozycki, Shruthi Venugopal, Katalin Szászi, Michael Kofler, András Kapus   +5 more
doaj   +1 more source

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

iScience, 2021
Summary: There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved.
Abrey J. Yeo, Kok L. Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah Withey, Ernst Wolvetang, Robert G. Parton, Adam D. Brown, Michael B. Kastan, David Coman, Martin F. Lavin   +11 more
doaj   +1 more source

Sequence-directed concentration of G protein-coupled receptors in COPII vesicles

iScience, 2023
Summary: G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma membrane signaling proteins. However, virtually nothing is known about their recruitment to COPII vesicles for forward delivery after synthesis in the endoplasmic ...
Xin Xu, Nevin A. Lambert, Guangyu Wu
doaj   +1 more source

Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration

iScience, 2022
Summary: Rab proteins are well known regulators of intracellular trafficking; however, more and more studies point to their function also in other cellular processes, including cell migration.
Synne Arstad Bjørnestad, Noemi Antonella Guadagno, Ingrid Kjos, Cinzia Progida   +3 more
doaj   +1 more source