Results 31 to 40 of about 759,413 (161)

Expression profiles of genes regulating dairy cow fertility: recent findings, ongoing activities and future possibilities [PDF]

open access: yes, 2008
Subfertility has negative effects for dairy farm profitability, animal welfare and sustainability of animal production. Increasing herd sizes and economic pressures restrict the amount of time that farmers can spend on counteractive management Genetic ...
Beerda, B.   +4 more
core   +2 more sources

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 [PDF]

open access: yes, 2014
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’ (ACD).
A Ciechanover   +438 more
core   +17 more sources

Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment

open access: yesiScience, 2022
Summary: Entosis is a cell competition process during which tumor cells engulf other tumor cells. It is initiated by metabolic stress or by loss of matrix adhesion, and it provides the winning cell with resources derived from the internalized cell. Using
Mariel F. Schwietzer   +8 more
doaj   +1 more source

Emergent global patterns of ecosystem structure and function from a mechanistic general ecosystem model [PDF]

open access: yes, 2014
Anthropogenic activities are causing widespread degradation of ecosystems worldwide, threatening the ecosystem services upon which all human life depends.
A Friedlander   +109 more
core   +4 more sources

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4

open access: yesiScience, 2023
Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang   +11 more
doaj   +1 more source

Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]

open access: yes, 2019
BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas   +5 more
core   +3 more sources

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading

open access: yesiScience
Summary: Cells sense mechanical cues and convert them into biochemical responses to regulate biological processes such as embryonic development, aging, cellular homeostasis, and disease progression.
Pei-Li Tseng   +7 more
doaj   +1 more source

Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology

open access: yesiScience, 2020
Summary: During collective cell migration, front cells tend to extend a predominant leading protrusion, which is rarely present in cells at the side or rear positions.
Heng Wang   +4 more
doaj   +1 more source

mRNA splicing is modulated by intronic microRNAs

open access: yesiScience, 2023
Summary: Splicing of transcripts is catalyzed by the spliceosome, a mega-complex consisting of hundreds of proteins and five snRNAs, which employs direct interactions. When U1 snRNA forms high-affinity binding, namely more than eight base pairs, with the
Luba Farberov   +7 more
doaj   +1 more source

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]

open access: yes, 2016
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune ...
Brandau, Sven   +14 more
core   +2 more sources

Home - About - Disclaimer - Privacy