Results 31 to 40 of about 298,134 (216)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition

iScience, 2020
Summary: Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing and increased membrane permeability. Caspase-1 and caspase-11 have been considered to be essential for gasdermin D processing associated with inflammasome
Emi Aizawa, Tadayoshi Karasawa, Sachiko Watanabe, Takanori Komada, Hiroaki Kimura, Ryo Kamata, Homare Ito, Erika Hishida, Naoya Yamada, Tadashi Kasahara, Yoshiyuki Mori, Masafumi Takahashi   +11 more
doaj   +1 more source

BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1

iScience, 2022
Summary: Tumors with BRCA1 mutations have poor prognoses due to genomic instability. Yet this genomic instability has risks and BRCA1-deficient (def) cancer cells must develop pathways to mitigate these risks.
Robert Hromas, Gayathri Srinivasan, Ming Yang, Aruna Jaiswal, Taylor A. Totterdale, Linda Phillips, Austin Kirby, Nazli Khodayari, Mark Brantley, Elizabeth A. Williamson, Kimi Y. Kong   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

How chromosomal translocations arise to cause cancer: Gene proximity, trans-splicing, and DNA end joining

iScience, 2023
Summary: Chromosomal translocations (CTs) are a genetic hallmark of cancer. They could be identified as recurrent genetic aberrations in hemato-malignancies and solid tumors. More than 40% of all “cancer genes” were identified in recurrent CTs.
Patrick Streb, Eric Kowarz, Tamara Benz, Jennifer Reis, Rolf Marschalek   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans

iScience
Summary: Vitellogenin is thought to share a common ancestor with human apolipoprotein B (ApoB) for systemic lipid transport. In Caenorhabditis elegans, although a general route for inter-tissue vitellogenin transport has been described, the full ...
Jimmy H. Mo, Chao Zhai, Kwangsek Jung, Yan Li, Yonghong Yan, Meng-Qiu Dong, Ho Yi Mak   +6 more
doaj   +1 more source

Both ANT and ATPase are essential for mitochondrial permeability transition but not depolarization

iScience, 2022
Summary: An increase in permeability of the mitochondrial inner membrane, mitochondrial permeability transition (PT), is the central event responsible for cell death and tissue damage in conditions such as stroke and heart attack.
M.A. Neginskaya, S.E. Morris, E.V. Pavlov   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Homo-oxidized HSPB1 protects H9c2 cells against oxidative stress via activation of KEAP1/NRF2 signaling pathway

iScience, 2023
Summary: Several heat shock proteins are implicated in the endogenous cardioprotective mechanisms, but little is known about the role of heat shock protein beta-1 (HSPB1).
Nian Wang, Xiehong Liu, Ke Liu, Kangkai Wang, Huali Zhang   +4 more
doaj   +1 more source