Results 31 to 40 of about 765,092 (159)

The Unicellular State as a Point Source in a Quantum Biological System. [PDF]

, 2016
A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific ...
Miller, William B, Torday, John S
core   +6 more sources

Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding

iScience, 2022
Summary: A delicate balance of BMP activity is critical for tissue formation and organogenesis. However, the mechanical molecular details in ensuring the proper duration and intensity of BMP signaling have yet to be fully elucidated.
Shuyan Yang, Guozhu Ning, Yiming Hou, Yu Cao, Jin Xu, Jianxin Wu, Ting Zhang, Qiang Wang   +7 more
doaj   +1 more source

Tricalbins Are Required for Non-vesicular Ceramide Transport at ER-Golgi Contacts and Modulate Lipid Droplet Biogenesis

iScience, 2020
Summary: Lipid composition varies among organelles, and the distinct lipid composition is important for specific functions of each membrane. Lipid transport between organelles, which is critical for the maintenance of membrane lipid composition, occurs ...
Atsuko Ikeda, Philipp Schlarmann, Kazuo Kurokawa, Akihiko Nakano, Howard Riezman, Kouichi Funato   +5 more
doaj   +1 more source

Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4

iScience, 2023
Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang, Xianxiong Ma, Guanxin Wei, Xiuxian Zhu, Peng Hu, Xiang Chen, Dianshi Wang, Yuan Li, Tuo Ruan, Weikang Zhang, Kaixiong Tao, Chuanqing Wu   +11 more
doaj   +1 more source

mRNA splicing is modulated by intronic microRNAs

iScience, 2023
Summary: Splicing of transcripts is catalyzed by the spliceosome, a mega-complex consisting of hundreds of proteins and five snRNAs, which employs direct interactions. When U1 snRNA forms high-affinity binding, namely more than eight base pairs, with the
Luba Farberov, Daphna Weissglas-Volkov, Guy Shapira, Yazeed Zoabi, Chen Schiff, Barbara Kloeckener-Gruissem, John Neidhardt, Noam Shomron   +7 more
doaj   +1 more source

The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in \u3cem\u3eC. elegans\u3c/em\u3e [PDF]

, 2016
The regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of proteins and is catalyzed by E1, E2, and E3 enzymes. The Anaphase-Promoting Complex
Jennings, Alexandra K., Kowalski, Jennifer R., Wang, Julia   +2 more
core   +3 more sources

SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway

iScience, 2022
Summary: Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Cancer cells differ in their sensitivity to ferroptosis.
Kun Fang, Sha Du, Dachuan Shen, Zhipeng Xiong, Ke Jiang, Dapeng Liang, Jianxin Wang, Huizhe Xu, Lulu Hu, Xingyue Zhai, Yuting Jiang, Zhiyu Xia, Chunrui Xie, Di Jin, Wei Cheng, Songshu Meng, Yifei Wang   +16 more
doaj   +1 more source

Emergent global patterns of ecosystem structure and function from a mechanistic general ecosystem model [PDF]

, 2014
Anthropogenic activities are causing widespread degradation of ecosystems worldwide, threatening the ecosystem services upon which all human life depends.
A Friedlander, A Hardisty, B Cho, B Collen, B-E Sæther, BJ McGill, C Mora, C Ward-Paige, CA Deutsch, CB Field, CD Thomas, CEL Ferreira, CH Sekercioglu, CM Duarte, CR McClain, D Griffiths, D Policansky, D Post, D Yates, Derek P. Tittensor, DG Jenkins, Drew W. Purves, DW Purves, E Jeppesen, E Macpherson, E Odum, E Siemann, EA Fulton, FS Chapin, G Krinner, GA Kaufman, GM Mace, H Cyr, H Stibor, HR Peinetti, J Cebrian, J Chase, J Gasol, J Merilä, JA Carton, JE Cohen, JH Brown, JL Frangi, JM Sunday, Jon Hutton, JP Rodríguez, JS Millar, Jörn P. W. Scharlemann, K Rose, KA Nagy, KA Schubert, KE Jones, KR Buck, L Tremblay-Boyer, LLM Fedigan, LW Oring, M Behrenfeld, M González-Suárez, Matthew J. Smith, MBJ Harfoot, ME Power, Michael B. J. Harfoot, Michel Loreau, MJ Coe, MJ Morgan, MJ Smith, MJ Vander Zanden, MK Litvak, MR Evans, MW McCoy, N Blakley, N Loeuille, NG Hairston, O Krüger, P Abrams, P Del Giorgio, PK Holland, R Alkemade, R Bustamante, R Gentile, R Meek, R Shine, R Shine, RE Ricklefs, RE Ricklefs, RJ Williams, RJ Williams, RW Sheldon, RW Wilson, S Díaz, S Fretwell, S Jain, S Jennings, S Jennings, S Meiri, S Sitch, SA Sandin, SD Pletcher, Stephen Emmott, T Newbold, T Sousa, Tim Newbold, TJ Case, TJ Webb, U Brose, V Christensen, Vassily Lyutsarev, W Sprules, X Irigoien, Y-J Shin   +109 more
core   +4 more sources

Bridging Physics and Biology Teaching through Modeling [PDF]

, 2013
As the frontiers of biology become increasingly interdisciplinary, the physics education community has engaged in ongoing efforts to make physics classes more relevant to life sciences majors.
Anne-Marie Hoskinson, Benjamin M. Zwickl, Brewer Carol A., Brian A. Couch, Brooker R., Chabay R. W., Cummings K., Etkina E., Giancoli D. C., Halloun I. A., Kathleen A. Hinko, Knight R. D., Levins R., Marcos D. Caballero, National Research Council, National Research Council, National Research Council, National Research Council, National Science Board, Raven P., Reece J. B., Rice J., Serway R. A., Starfield A. M.   +23 more
core   +3 more sources

Loss of contact inhibition of locomotion in the absence of JAM-A promotes entotic cell engulfment

iScience, 2022
Summary: Entosis is a cell competition process during which tumor cells engulf other tumor cells. It is initiated by metabolic stress or by loss of matrix adhesion, and it provides the winning cell with resources derived from the internalized cell. Using
Mariel F. Schwietzer, Sonja Thölmann, Daniel Kummer, Anne Kaschler, Lilo Greune, Eva-Maria Thüring, M. Alexander Schmidt, Volker Gerke, Klaus Ebnet   +8 more
doaj   +1 more source