Results 11 to 20 of about 298,134 (216)

Differential N-terminal processing of beta and gamma actin

iScience, 2022
Summary: Cytoplasmic beta- and gamma-actin are ubiquitously expressed in every eukaryotic cell. They are encoded by different genes, but their amino acid sequences differ only by four conservative substitutions at the N-termini, making it difficult to ...
Li Chen, Pavan Vedula, Hsin Yao Tang, Dawei W. Dong, Anna S. Kashina   +4 more
doaj   +1 more source

Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin

iScience, 2022
Summary: The microfibril-forming collagen VI is proteolytically cleaved and it was proposed that the released C-terminal Kunitz domain (C5) of the α3 chain is an adipokine important for tumor progression and fibrosis.
Matthias Przyklenk, Stefanie Elisabeth Heumüller, Carolin Freiburg, Steffen Lütke, Gerhard Sengle, Manuel Koch, Mats Paulsson, Alvise Schiavinato, Raimund Wagener   +8 more
doaj   +1 more source

Mitotic HOOK3 phosphorylation by ERK1c drives microtubule-dependent Golgi destabilization and fragmentation

iScience, 2021
Summary: ERK1c is an alternatively spliced isoform of ERK1 that specifically regulates mitotic Golgi fragmentation, which allows division of the Golgi during mitosis.
Inbal Wortzel, Galia Maik-Rachline, Suresh Singh Yadav, Tamar Hanoch, Rony Seger   +4 more
doaj   +1 more source

Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production

iScience, 2021
Summary: Exosomes are important for cell–cell communication. Deficiencies in the human dihydroceramide desaturase gene, DEGS1, increase the dihydroceramide-to-ceramide ratio and cause hypomyelinating leukodystrophy. However, the disease mechanism remains
Chen-Yi Wu, Jhih-Gang Jhang, Wan-Syuan Lin, Pei-Huan Chuang, Chih-Wei Lin, Li-An Chu, Ann-Shyn Chiang, Han-Chen Ho, Chih-Chiang Chan, Shu-Yi Huang   +9 more
doaj   +1 more source

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

iScience, 2022
Summary: IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The mechanisms underlying these processes are not known. We report that IL11-stimulated ERK/P90RSK activity causes the phosphorylation of LKB1 at S325 and S428 ...
Anissa A. Widjaja, Sivakumar Viswanathan, Joyce Goh Wei Ting, Jessie Tan, Shamini G. Shekeran, David Carling, Wei-Wen Lim, Stuart A. Cook   +7 more
doaj   +1 more source

Internalization-Dependent Free Fatty Acid Receptor 2 Signaling Is Essential for Propionate-Induced Anorectic Gut Hormone Release

iScience, 2020
Summary: The ability of propionate, a short-chain fatty acid produced from the fermentation of non-digestible carbohydrates in the colon, to stimulate the release of anorectic gut hormones, such as glucagon like peptide-1 (GLP-1), is an attractive ...
Natarin Caengprasath, Noemi Gonzalez-Abuin, Maria Shchepinova, Yue Ma, Asuka Inoue, Edward W. Tate, Gary Frost, Aylin C. Hanyaloglu   +7 more
doaj   +1 more source

Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties

iScience, 2022
Summary: Fertilized eggs begin to translate mRNAs at appropriate times and placements to control development, but how the translation is regulated remains unclear.
Keisuke Sato, Moeko Sakai, Anna Ishii, Kaori Maehata, Yuki Takada, Kyota Yasuda, Tomoya Kotani   +6 more
doaj   +1 more source

Contribution of septins to human platelet structure and function

iScience, 2022
Summary: Although septins have been well-studied in nucleated cells, their role in anucleate blood platelets remains obscure. Here, we elucidate the contribution of septins to human platelet structure and functionality. We show that Septin-2 and Septin-9
Oleg V. Kim, Rustem I. Litvinov, Elmira R. Mordakhanova, Erfei Bi, Olga Vagin, John W. Weisel   +5 more
doaj   +1 more source

ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability

iScience, 2021
Summary: DNA double-strand break (DSB) repair by homologous recombination (HR) is essential for ensuring genome stability. Abnormal spindle-like microcephaly-associated (ASPM) gene encodes a spindle protein that is commonly implicated in primary ...
Shibin Xu, Xingxuan Wu, Peipei Wang, Sheng-Li Cao, Bin Peng, Xingzhi Xu   +5 more
doaj   +1 more source

Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

iScience, 2023
Summary: The DNA-damage response is a complex signaling network that guards genomic integrity. The microtubule cytoskeleton is involved in the repair of DNA double-strand breaks; however, little is known about which cytoskeleton-related proteins are ...
Arlinda Dullovi, Meryem Ozgencil, Vinothini Rajvee, Wai Yiu Tse, Pedro R. Cutillas, Sarah A. Martin, Zuzana Hořejší   +6 more
doaj   +1 more source