Results 1 to 10 of about 77,766 (144)

Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration

iScience, 2022
Summary: Rab proteins are well known regulators of intracellular trafficking; however, more and more studies point to their function also in other cellular processes, including cell migration.
Synne Arstad Bjørnestad, Noemi Antonella Guadagno, Ingrid Kjos, Cinzia Progida   +3 more
doaj   +3 more sources

Constitutive activation of S1P receptors at the trans-Golgi network is required for surface transport carrier formation

iScience, 2021
Summary: The importance of the G-protein βγ subunits in the regulation of cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PM) is well accepted; however, the molecular mechanism underlying the G-protein activation at the TGN ...
Taro Okada, Susumu Nishida, Lifang Zhang, Nesma Nabil Ibrahim Mohamed, Tianyou Wang, Takeshi Ijuin, Taketoshi Kajimoto, Shun-Ichi Nakamura   +7 more
doaj   +3 more sources

Septin 9 and phosphoinositides regulate lysosome localization and their association with lipid droplets

iScience, 2022
Summary: The accumulation of lipid droplets (LDs) in the liver is a hallmark of steatosis, which is often associated with lysosomal dysfunction. Nevertheless, the underlying mechanisms remain unclear.
Pei Xuan Song, Juan Peng, Mohyeddine Omrane, Ting ting Cai, Didier Samuel, Ama Gassama-Diagne   +5 more
doaj   +3 more sources

Categorization of lung mesenchymal cells in development and fibrosis

iScience, 2021
Summary: Pulmonary mesenchymal cells are critical players in both the mouse and human during lung development and disease states. They are increasingly recognized as highly heterogeneous, but there is no consensus on subpopulations or discriminative ...
Xue Liu, Simon C. Rowan, Jiurong Liang, Changfu Yao, Guanling Huang, Nan Deng, Ting Xie, Di Wu, Yizhou Wang, Ankita Burman, Tanyalak Parimon, Zea Borok, Peter Chen, William C. Parks, Cory M. Hogaboam, S. Samuel Weigt, John Belperio, Barry R. Stripp, Paul W. Noble, Dianhua Jiang   +19 more
doaj   +3 more sources

FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells

iScience, 2021
Summary: At the initial stage of carcinogenesis, cell competition often occurs between newly emerging transformed cells and the neighboring normal cells, leading to the elimination of transformed cells from the epithelial layer. For instance, when RasV12-
Tomoko Kamasaki, Yumi Miyazaki, Susumu Ishikawa, Kazuya Hoshiba, Keisuke Kuromiya, Nobuyuki Tanimura, Yusuke Mori, Motosuke Tsutsumi, Tomomi Nemoto, Ryota Uehara, Shiro Suetsugu, Toshiki Itoh, Yasuyuki Fujita   +12 more
doaj   +3 more sources

Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology

iScience, 2020
Summary: During collective cell migration, front cells tend to extend a predominant leading protrusion, which is rarely present in cells at the side or rear positions.
Heng Wang, Xuan Guo, Xianping Wang, Xiaobo Wang, Jiong Chen   +4 more
doaj   +3 more sources

A nucleation distance sets the cell size-dependent P-body assembly in yeast [PDF]

iScience
Summary: Cells rely on diverse intracellular structures, including phase-separated granules, to regulate biological processes. Processing bodies (P-bodies) are membraneless cytoplasmic condensates that mediate mRNA degradation and storage. Although their
Xuefang Gu, Hamza El Alami, Dexin Shen, Xing Quan, Tatsuhisa Tsuboi   +4 more
doaj   +2 more sources

CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

iScience, 2021
Summary: CHIP is an E3-ubiquitin ligase that contributes to healthy aging and has been characterized as neuroprotective. To elucidate dominant CHIP-dependent changes in protein steady-state levels in a patient-derived human neuronal model, CHIP function ...
Catarina Dias, Erisa Nita, Jakub Faktor, Ailish C. Tynan, Lenka Hernychova, Borivoj Vojtesek, Jesper Nylandsted, Ted R. Hupp, Tilo Kunath, Kathryn L. Ball   +9 more
doaj   +3 more sources

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading

iScience
Summary: Cells sense mechanical cues and convert them into biochemical responses to regulate biological processes such as embryonic development, aging, cellular homeostasis, and disease progression.
Pei-Li Tseng, Weiwei Sun, Ahmed Salem, Mubarak Alaklobie, Sarah C. Macfarlane, Annica K.B. Gad, Mark O. Collins, Kai S. Erdmann   +7 more
doaj   +3 more sources

Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

iScience, 2023
Summary: PARP1 contributes to genome architecture and DNA damage repair through its dynamic association with chromatin. PARP1 and PARP2 (PARP1/2) recognize damaged DNA and recruit the DNA repair machinery.
Jyothi Mahadevan, Asmita Jha, Johannes Rudolph, Samuel Bowerman, Domenic Narducci, Anders S. Hansen, Karolin Luger   +6 more
doaj   +3 more sources