Results 11 to 20 of about 78,797 (204)

Glycemia Regulation: From Feedback Loops to Organizational Closure. [PDF]

, 2020
Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain bodily functions such as glucose metabolism. In particular, feedback loops focus on the maintenance of the plasma concentrations of glucose within a narrow range ...
Bich, Leonardo, Mossio, Matteo, Soto, Ana M.   +2 more
core   +5 more sources

Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]

, 2010
The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem, Bali Pulendran, Rino Rappuoli, the Working Group convened by the Global HIV Vaccine Enterprise   +3 more
core   +5 more sources

Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo

iScience, 2022
Summary: Metastasis is tightly linked with poor cancer prognosis, yet it is not clear how transformed cells become invasive carcinomas. We previously discovered that single KRasV12-transformed cells can invade directly from the epithelium by basal cell ...
Teresa Zulueta-Coarasa, John Fadul, Marjana Ahmed, Jody Rosenblatt   +3 more
doaj   +1 more source

Categorization of lung mesenchymal cells in development and fibrosis

iScience, 2021
Summary: Pulmonary mesenchymal cells are critical players in both the mouse and human during lung development and disease states. They are increasingly recognized as highly heterogeneous, but there is no consensus on subpopulations or discriminative ...
Xue Liu, Simon C. Rowan, Jiurong Liang, Changfu Yao, Guanling Huang, Nan Deng, Ting Xie, Di Wu, Yizhou Wang, Ankita Burman, Tanyalak Parimon, Zea Borok, Peter Chen, William C. Parks, Cory M. Hogaboam, S. Samuel Weigt, John Belperio, Barry R. Stripp, Paul W. Noble, Dianhua Jiang   +19 more
doaj   +1 more source

FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells

iScience, 2021
Summary: At the initial stage of carcinogenesis, cell competition often occurs between newly emerging transformed cells and the neighboring normal cells, leading to the elimination of transformed cells from the epithelial layer. For instance, when RasV12-
Tomoko Kamasaki, Yumi Miyazaki, Susumu Ishikawa, Kazuya Hoshiba, Keisuke Kuromiya, Nobuyuki Tanimura, Yusuke Mori, Motosuke Tsutsumi, Tomomi Nemoto, Ryota Uehara, Shiro Suetsugu, Toshiki Itoh, Yasuyuki Fujita   +12 more
doaj   +1 more source

Spatial topology of organelle is a new breast cancer cell classifier

iScience, 2023
Summary: Genomics and proteomics have been central to identify tumor cell populations, but more accurate approaches to classify cell subtypes are still lacking.
Ling Wang, Joshua Goldwag, Megan Bouyea, Jonathan Barra, Kailie Matteson, Niva Maharjan, Amina Eladdadi, Mark J. Embrechts, Xavier Intes, Uwe Kruger, Margarida Barroso   +10 more
doaj   +1 more source

Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology

iScience, 2020
Summary: During collective cell migration, front cells tend to extend a predominant leading protrusion, which is rarely present in cells at the side or rear positions.
Heng Wang, Xuan Guo, Xianping Wang, Xiaobo Wang, Jiong Chen   +4 more
doaj   +1 more source

Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex

iScience, 2021
Summary: Remodeling of mitochondrial ultrastructure is a process that is critical for organelle physiology and apoptosis. Although the key players in this process—mitochondrial contact site and cristae junction organizing system (MICOS) and Optic Atrophy
Martonio Ponte Viana, Roman M. Levytskyy, Ruchika Anand, Andreas S. Reichert, Oleh Khalimonchuk   +4 more
doaj   +1 more source

The Evolutionary Reorganization of Ontogeny and Origin of Multicellularity [PDF]

, 2010
The formation of morphogenetic mechanisms during emergence of multicellularity is discussed in this ...
Dovgal, I. V.
core   +1 more source

DNA sequence-directed cooperation between nucleoid-associated proteins

iScience, 2021
Summary: Nucleoid-associated proteins (NAPs) are a class of highly abundant DNA-binding proteins in bacteria and archaea. While both the composition and relative abundance of the NAPs change during the bacterial growth cycle, surprisingly little is known
Aleksandre Japaridze, Wayne Yang, Cees Dekker, William Nasser, Georgi Muskhelishvili   +4 more
doaj   +1 more source