Results 11 to 20 of about 77,865 (243)
Integrated analysis of glycan and RNA in single cells
iScience, 2021 Summary: Single-cell sequencing has emerged as an indispensable technology to dissect cellular heterogeneity but never been applied to the simultaneous analysis of glycan and RNA.
Fumi Minoshima +3 more
doaj +3 more sources
Dynein-Mediated Regional Cell Division Reorientation Shapes a Tailbud Embryo
iScience, 2020 Summary: Regulation of cell division orientation controls the spatial distribution of cells during development and is essential for one-directional tissue transformation, such as elongation. However, little is known about whether it plays a role in other
Ayaki Nakamoto, Gaku Kumano
doaj +3 more sources
iScience, 2019 Summary: Cytoskeletal cross talk between actin filaments and microtubules is a common mechanism governing the assembly of cellular structures, i.e., during filopodia formation or cilia organization.
Matthias Plessner +2 more
doaj +3 more sources
iScience, 2021 Summary: Turnover of the primary cilium (PC) is critical for proliferation and tissue homeostasis. Each key component of the PC resorption machinery, the HEF1/Aurora kinase A (AurA)/HDAC6 pathway harbors cis-elements potentially targeted by the ...
Pam Speight +5 more
doaj +1 more source
Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia
iScience, 2021 Summary: There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved.
Abrey J. Yeo +11 more
doaj +1 more source
Novel approaches, including systems biology, to HIV vaccine research and development: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a two-day workshop on August 10-11 2009, at the Fred Hutchison Cancer Research Center offices in Seattle, WA, to discuss the application of novel approaches,including systems biology, to HIV vaccine research and
Alan Aderem +3 more
core +5 more sources
iScience, 2022 Summary: Fertilized eggs begin to translate mRNAs at appropriate times and placements to control development, but how the translation is regulated remains unclear.
Keisuke Sato +6 more
doaj +1 more source
Glycemia Regulation: From Feedback Loops to Organizational Closure. [PDF]
, 2020 Endocrinologists apply the idea of feedback loops to explain how hormones regulate certain bodily functions such as glucose metabolism. In particular, feedback loops focus on the maintenance of the plasma concentrations of glucose within a narrow range ...
Bich, Leonardo +2 more
core +5 more sources
Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance
iScience, 2023 Summary: The liver has long been deemed a tolerogenic organ. We employed high-dimensional mass cytometry and immunohistochemistry to depict the temporal and spatial dynamics of immune cells in the spleen and liver in a murine model of spontaneous liver ...
Weitao Que +10 more
doaj +1 more source
iScience, 2022 Summary: Metastasis is tightly linked with poor cancer prognosis, yet it is not clear how transformed cells become invasive carcinomas. We previously discovered that single KRasV12-transformed cells can invade directly from the epithelium by basal cell ...
Teresa Zulueta-Coarasa +3 more
doaj +1 more source