Results 11 to 20 of about 9,035 (208)

Centrosomal Actin Assembly Is Required for Proper Mitotic Spindle Formation and Chromosome Congression

iScience, 2019
Summary: Cytoskeletal cross talk between actin filaments and microtubules is a common mechanism governing the assembly of cellular structures, i.e., during filopodia formation or cilia organization.
Matthias Plessner, Julian Knerr, Robert Grosse   +2 more
doaj   +3 more sources

Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms

iScience, 2021
Summary: Turnover of the primary cilium (PC) is critical for proliferation and tissue homeostasis. Each key component of the PC resorption machinery, the HEF1/Aurora kinase A (AurA)/HDAC6 pathway harbors cis-elements potentially targeted by the ...
Pam Speight, Matthew Rozycki, Shruthi Venugopal, Katalin Szászi, Michael Kofler, András Kapus   +5 more
doaj   +1 more source

Impaired endoplasmic reticulum-mitochondrial signaling in ataxia-telangiectasia

iScience, 2021
Summary: There is evidence that ATM mutated in ataxia-telangiectasia (A-T) plays a key role in protecting against mitochondrial dysfunction, the mechanism for which remains unresolved.
Abrey J. Yeo, Kok L. Chong, Magtouf Gatei, Dongxiu Zou, Romal Stewart, Sarah Withey, Ernst Wolvetang, Robert G. Parton, Adam D. Brown, Michael B. Kastan, David Coman, Martin F. Lavin   +11 more
doaj   +1 more source

Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties

iScience, 2022
Summary: Fertilized eggs begin to translate mRNAs at appropriate times and placements to control development, but how the translation is regulated remains unclear.
Keisuke Sato, Moeko Sakai, Anna Ishii, Kaori Maehata, Yuki Takada, Kyota Yasuda, Tomoya Kotani   +6 more
doaj   +1 more source

Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance

iScience, 2023
Summary: The liver has long been deemed a tolerogenic organ. We employed high-dimensional mass cytometry and immunohistochemistry to depict the temporal and spatial dynamics of immune cells in the spleen and liver in a murine model of spontaneous liver ...
Weitao Que, Hisashi Ueta, Xin Hu, Miwa Morita-Nakagawa, Masayuki Fujino, Daisuke Ueda, Nobuko Tokuda, Wenxin Huang, Wen-Zhi Guo, Lin Zhong, Xiao-Kang Li   +10 more
doaj   +1 more source

Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo

iScience, 2022
Summary: Metastasis is tightly linked with poor cancer prognosis, yet it is not clear how transformed cells become invasive carcinomas. We previously discovered that single KRasV12-transformed cells can invade directly from the epithelium by basal cell ...
Teresa Zulueta-Coarasa, John Fadul, Marjana Ahmed, Jody Rosenblatt   +3 more
doaj   +1 more source

Spatial topology of organelle is a new breast cancer cell classifier

iScience, 2023
Summary: Genomics and proteomics have been central to identify tumor cell populations, but more accurate approaches to classify cell subtypes are still lacking.
Ling Wang, Joshua Goldwag, Megan Bouyea, Jonathan Barra, Kailie Matteson, Niva Maharjan, Amina Eladdadi, Mark J. Embrechts, Xavier Intes, Uwe Kruger, Margarida Barroso   +10 more
doaj   +1 more source

Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex

iScience, 2021
Summary: Remodeling of mitochondrial ultrastructure is a process that is critical for organelle physiology and apoptosis. Although the key players in this process—mitochondrial contact site and cristae junction organizing system (MICOS) and Optic Atrophy
Martonio Ponte Viana, Roman M. Levytskyy, Ruchika Anand, Andreas S. Reichert, Oleh Khalimonchuk   +4 more
doaj   +1 more source

DNA sequence-directed cooperation between nucleoid-associated proteins

iScience, 2021
Summary: Nucleoid-associated proteins (NAPs) are a class of highly abundant DNA-binding proteins in bacteria and archaea. While both the composition and relative abundance of the NAPs change during the bacterial growth cycle, surprisingly little is known
Aleksandre Japaridze, Wayne Yang, Cees Dekker, William Nasser, Georgi Muskhelishvili   +4 more
doaj   +1 more source

Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells

iScience, 2023
Summary: We present a study on the nuclear export efficiency and time of pre-ribosomal subunits in live mammalian cells, using high-speed single-molecule tracking and single-molecule fluorescence resonance energy transfer techniques.
Samuel L. Junod, Mark Tingey, Joseph M. Kelich, Alexander Goryaynov, Karl Herbine, Weidong Yang   +5 more
doaj   +1 more source