Results 31 to 40 of about 78,797 (204)

Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease

Nature Reviews Neurology, 2023
High-throughput single-cell technologies enable multiple layers of molecular biology to be probed at the single-cell level. Single-cell transcriptomic atlases spanning multiple developmental stages have been generated with the aim of dissecting the ...
Monika Piwecka, N. Rajewsky, A. Rybak-Wolf   +2 more
semanticscholar   +1 more source

Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation

iScience, 2022
Summary: Hsp70 is a key molecular chaperone in the protein quality control system to safeguard protein homeostasis in cells. Previous studies have shown that Hsp70 chaperones TDP-43, a pathogenic protein associated with amyotrophic lateral sclerosis (ALS)
Yichen Li, Jinge Gu, Chen Wang, Jiaojiao Hu, Shenqing Zhang, Cong Liu, Shengnan Zhang, Yanshan Fang, Dan Li   +8 more
doaj   +1 more source

ORGANIZATIONAL AND ECONOMIC ASPECTS OF CLINICAL AND LABORATORY ACTIVITIES - POSSIBILITIES AND PERSPECTIVES OF OPTIMIZATION

Knowledge International Journal, 2019
“Clinical Laboratory” is an independent medical specialty, a dynamic clinical discipline of a scientific and applied nature. Laboratory researches, the results of which are objective indicators of the state of the organism, are of great importance in ...
Nikola Sabev, Denitsa Trancheva
semanticscholar   +1 more source

CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

iScience, 2021
Summary: CHIP is an E3-ubiquitin ligase that contributes to healthy aging and has been characterized as neuroprotective. To elucidate dominant CHIP-dependent changes in protein steady-state levels in a patient-derived human neuronal model, CHIP function ...
Catarina Dias, Erisa Nita, Jakub Faktor, Ailish C. Tynan, Lenka Hernychova, Borivoj Vojtesek, Jesper Nylandsted, Ted R. Hupp, Tilo Kunath, Kathryn L. Ball   +9 more
doaj   +1 more source

Organizational aspects of tissue engineering clinical translation: insights from a qualitative case study

Translational Medicine Communications
Tissue engineering is a multidisciplinary field that combines principles from cell biology, bioengineering, material sciences, medicine and surgery to create functional and viable bioproducts that can be used to repair or replace damaged or diseased ...
Renan Gonçalves Leonel da Silva, Larry Au, A. Blasimme   +2 more
semanticscholar   +1 more source

Wiring optimization explanation in neuroscience: What is Special about it? [PDF]

, 2019
This paper examines the explanatory distinctness of wiring optimization models in neuroscience. Wiring optimization models aim to represent the organizational features of neural and brain systems as optimal (or near-optimal) solutions to wiring ...
Barberis, Sergio Daniel
core   +6 more sources

Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading

iScience
Summary: Cells sense mechanical cues and convert them into biochemical responses to regulate biological processes such as embryonic development, aging, cellular homeostasis, and disease progression.
Pei-Li Tseng, Weiwei Sun, Ahmed Salem, Mubarak Alaklobie, Sarah C. Macfarlane, Annica K.B. Gad, Mark O. Collins, Kai S. Erdmann   +7 more
doaj   +1 more source

Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration

Genes, 2021
The question of why animals vary in their ability to regenerate remains one of the most intriguing questions in biology. Annelids are a large and diverse phylum, many members of which are capable of extensive regeneration such as regrowth of a complete ...
R. P. Kostyuchenko, V. Kozin
semanticscholar   +1 more source

A quantitative perspective on ethics in large team science [PDF]

, 2014
The gradual crowding out of singleton and small team science by large team endeavors is challenging key features of research culture. It is therefore important for the future of scientific practice to reflect upon the individual scientist's ethical ...
Pavlidis, Ioannis, Petersen, Alexander M., Semendeferi, Ioanna   +2 more
core   +2 more sources

Integrated analysis of glycan and RNA in single cells

iScience, 2021
Summary: Single-cell sequencing has emerged as an indispensable technology to dissect cellular heterogeneity but never been applied to the simultaneous analysis of glycan and RNA.
Fumi Minoshima, Haruka Ozaki, Haruki Odaka, Hiroaki Tateno   +3 more
doaj   +1 more source