Results 41 to 50 of about 78,797 (204)

Computational Cancer Biology: An Evolutionary Perspective [PDF]

, 2016
ISSN:1553-734XISSN:1553 ...
A Deutsch, A Fischer, A Gonzalez-Perez, A Roth, A Schuh, A Tofigh, A Trinh, AM Newman, BJ Raphael, C Guichard, C Tomasetti, C Tomasetti, CD Greenman, Chris D. Greenman, CO Nordling, CS Cooper, CS-O Attolini, E Purdom, E Szczurek, ER Fearon, F Michor, F Ronquist, F Strino, F Vandin, H Shahrabi Farahani, H Zare, I Bozic, I Bozic, I Martincorena, J Diaz, J Foo, J Rahnenführer, J Shendure, Jens Lagergren, JH Goldie, K Yuan, KI Kim, L Oesper, LJ Barber, LMF Merlo, LR Yates, M Consequences, M Gerlinger, M Gerstung, M Gerstung, M Gerstung, M Hjelm, M Kimmel, MDM Leiserson, MDM Leiserson, MDM Leiserson, MF Berger, MS Lawrence, N Beerenwinkel, N Beerenwinkel, N Beerenwinkel, N Crosetto, N Navin, NE Navin, Niko Beerenwinkel, P Armitage, P Eirew, P Haccou, PC Nowell, PS Larson, R Desper, R Durrett, RF Schwarz, Ruth Nussinov, S Constantinescu, S Nik-Zainal, S Nik-Zainal, S Turajlic, S Turajlic, SA Chowdhury, SA Chowdhury, SE Luria, T Sakoparnig, V Almendro, W Jiao, WJ Ewens, Y Iwasa   +81 more
core   +2 more sources

Microfibrous Scaffolds Guide Stem Cell Lumenogenesis and Brain Organoid Engineering

Advances in Materials, 2023
3D organoids are widely used as tractable in vitro models capable of elucidating aspects of human development and disease. However, the manual and low‐throughput culture methods, coupled with a low reproducibility and geometric heterogeneity, restrict ...
Kaja I Ritzau-Reid, S. Callens, Ruoxiao Xie, M. Cihova, Daniel Reumann, Christopher L. Grigsby, Lino Prados-Martin, Richard Wang, A. Moore, J. P. Armstrong, Juergen A. Knoblich, M. Stevens   +11 more
semanticscholar   +1 more source

Mammalian telomeres and their partnership with lamins [PDF]

, 2016
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA, LA TORRE, MATTIA, SAGGIO, Isabella   +2 more
core   +1 more source

Integrative biology of native cell extracts: a new era for structural characterization of life processes

Biological chemistry, 2019
Advances in electron microscopy have provided unprecedented access to the structural characterization of large, flexible and heterogeneous complexes. Until recently, cryo-electron microscopy (cryo-EM) has been applied to understand molecular organization
F. L. Kyrilis, A. Meister, P. Kastritis
semanticscholar   +1 more source

Towards a Model of Life and Cognition [PDF]

, 2004
What should be the ontology of the world such that life and cognition are possible? In this essay, I undertake to outline an alternative ontological foundation which makes biological and cognitive phenomena possible.
G., Nagarjuna
core  

Myosin cluster dynamics determines epithelial wound ring constriction

iScience
Summary: Collection of myosin motors and actin filaments can self-assemble into submicrometric clusters under the regulation of RhoA. Emergent dynamics of these clusters have been reported in a variety of morphogenetic systems, ranging from Drosophila to
Alka Bhat, Rémi Berthoz, Simon Lo Vecchio, Coralie Spiegelhalter, Shigenobu Yonemura, Olivier Pertz, Daniel Riveline   +6 more
doaj   +1 more source

Deciphering the interplay between biology and physics with a finite element method-implemented vertex organoid model: A tool for the mechanical analysis of cell behavior on a spherical organoid shell

PLoS Comput. Biol.
Understanding the interplay between biology and mechanics in tissue architecture is challenging, particularly in terms of 3D tissue organization. Addressing this challenge requires a biological model enabling observations at multiple levels from cell to ...
J. Laussu, D. Michel, L. Magne, S. Segonds, S. Marguet, D. Hamel, M. Quaranta-Nicaise, F. Barreau, E. Mas, Vincent Velay, F. Bugarin, A. Ferrand   +11 more
semanticscholar   +1 more source

Systems biology in animal sciences [PDF]

, 2011
Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Bannink, A., Pas, M.F.W., te, Smits, M.A., Veerkamp, R.F., Woelders, H.   +4 more
core   +3 more sources

Cryo-ET of actin cytoskeleton and membrane structure in lamellipodia formation using optogenetics

iScience
Summary: Lamellipodia are sheet-like protrusions essential for cell migration and endocytosis, but their ultrastructural dynamics remain poorly understood because conventional electron microscopy lacks temporal resolution.
Hironori Inaba, Tsuyoshi Imasaki, Kazuhiro Aoyama, Shogo Yoshihara, Hiroko Takazaki, Takayuki Kato, Hidemasa Goto, Kaoru Mitsuoka, Ryo Nitta, Takao Nakata   +9 more
doaj   +1 more source

Limiting 20S proteasome assembly leads to unbalanced nucleo-cytoplasmic distribution of 26S/30S proteasomes and chronic proteotoxicity

iScience
Summary: In addition to the degradation of cell-cycle proteins, short-lived, damaged, or unfolded proteins are constantly cleared from cells by the proteasome.
Gabriel Ruiz-Romero, María Dolores Berdún, Mark Hochstrasser, Silvia Salas-Pino, Rafael R. Daga   +4 more
doaj   +1 more source