Results 21 to 30 of about 77,865 (243)

Spatial topology of organelle is a new breast cancer cell classifier

iScience, 2023
Summary: Genomics and proteomics have been central to identify tumor cell populations, but more accurate approaches to classify cell subtypes are still lacking.
Ling Wang, Joshua Goldwag, Megan Bouyea, Jonathan Barra, Kailie Matteson, Niva Maharjan, Amina Eladdadi, Mark J. Embrechts, Xavier Intes, Uwe Kruger, Margarida Barroso   +10 more
doaj   +1 more source

Protease OMA1 modulates mitochondrial bioenergetics and ultrastructure through dynamic association with MICOS complex

iScience, 2021
Summary: Remodeling of mitochondrial ultrastructure is a process that is critical for organelle physiology and apoptosis. Although the key players in this process—mitochondrial contact site and cristae junction organizing system (MICOS) and Optic Atrophy
Martonio Ponte Viana, Roman M. Levytskyy, Ruchika Anand, Andreas S. Reichert, Oleh Khalimonchuk   +4 more
doaj   +1 more source

The Algorithmic Origins of Life [PDF]

, 2012
Although it has been notoriously difficult to pin down precisely what it is that makes life so distinctive and remarkable, there is general agreement that its informational aspect is one key property, perhaps the key property.
Cairns-Smith AG, Campbell DT, Cline DB, Davies PCW, Davies PCW, Ellis GFR, Gesteland RF, Hofstadter D, Kauffman S, Kolmogorov AN, Küppers BO, Paul C. W. Davies, Pearl J, Poundstone W, Sara Imari Walker, Schrödinger E, Segré D, Shaprio R, von Neumann J, Walker SI, Whitesides G   +20 more
core   +1 more source

DNA sequence-directed cooperation between nucleoid-associated proteins

iScience, 2021
Summary: Nucleoid-associated proteins (NAPs) are a class of highly abundant DNA-binding proteins in bacteria and archaea. While both the composition and relative abundance of the NAPs change during the bacterial growth cycle, surprisingly little is known
Aleksandre Japaridze, Wayne Yang, Cees Dekker, William Nasser, Georgi Muskhelishvili   +4 more
doaj   +1 more source

The Evolutionary Reorganization of Ontogeny and Origin of Multicellularity [PDF]

, 2010
The formation of morphogenetic mechanisms during emergence of multicellularity is discussed in this ...
Dovgal, I. V.
core   +1 more source

Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells

iScience, 2023
Summary: We present a study on the nuclear export efficiency and time of pre-ribosomal subunits in live mammalian cells, using high-speed single-molecule tracking and single-molecule fluorescence resonance energy transfer techniques.
Samuel L. Junod, Mark Tingey, Joseph M. Kelich, Alexander Goryaynov, Karl Herbine, Weidong Yang   +5 more
doaj   +1 more source

Synthetic biology—putting engineering into biology [PDF]

, 2006
Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we ...
Heinemann, Matthias,, Panke, Sven,
core   +1 more source

Systems biology in animal sciences [PDF]

, 2011
Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Bannink, A., Pas, M.F.W., te, Smits, M.A., Veerkamp, R.F., Woelders, H.   +4 more
core   +3 more sources

Super-resolution microscopy reveals nanoscale architecture and regulation of podosome clusters in primary macrophages

iScience, 2022
Summary: Podosomes, an important actin-based adhesive architecture, play critical roles in cell migration and matrix invasiveness. Here, we elucidate the ultrastructural organization and regulation of podosome clusters in primary macrophages.
Fen Hu, Donglan Zhu, Hao Dong, Ping Zhang, Fulin Xing, Wan Li, Rui Yan, Jun Zhou, Ke Xu, Leiting Pan, Jingjun Xu   +10 more
doaj   +1 more source

Mammalian telomeres and their partnership with lamins [PDF]

, 2016
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA, LA TORRE, MATTIA, SAGGIO, Isabella   +2 more
core   +1 more source