Results 331 to 340 of about 14,507,937 (378)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Unveiling Key Genes and Crucial Pathways in Goose Muscle Satellite Cell Biology Through Integrated Transcriptomic and Metabolomic Analyses. [PDF]

Int J Mol Sci
Liu Y, Wang C, Li M, Yang Y, Wang H, Chen S, He D.   +6 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

The cell biology of APOE in the brain. [PDF]

Trends Cell Biol
Windham IA, Cohen S.
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Xenon plasma focused ion beam lamella fabrication on high-pressure frozen specimens for structural cell biology. [PDF]

Nat Commun
Berger C, Watson H, Naismith JH, Dumoux M, Grange M.   +4 more
europepmc   +1 more source

Retinal Cell Biology in Health and Disease. [PDF]

Cells
Ameri H.
europepmc   +1 more source

The Collaborative Spark That Ignited the Field of Stromal Stem Cell Biology. [PDF]

Bioengineering (Basel)
Triffitt JT.
europepmc   +1 more source

A combined AI and cell biology approach surfaces targets and mechanistically distinct Inflammasome inhibitors. [PDF]

iScience
Chen D, Plott T, Wiest M, Van Trump W, Komalo B, Nguyen D, Marsh C, Heinrich J, Fuller CJ, Nicolaisen L, Cambronero E, Nguyen A, Elabd C, Rubbo F, DeVay Jacobson R.   +14 more
europepmc   +1 more source