Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Ascitic fluid polymorphic nuclear cell count impacts on outcome of cirrhotic patients with ascites [PDF]
, 2019 Benedikt Simbrunner +12 more
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Low-Dose Fluconazole as Primary Prophylaxis for Cryptococcal Infection in AIDS Patients with CD4 Cell Counts of <=100/mm3: Demonstration of Efficacy in a Prospective, Multicenter Trial [PDF]
, 1996 N. Singh +6 more
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Prognostic Role of Different Blood Cell Count-to-Lymphocyte Ratios in Patients with Lung Cancer at Diagnosis. [PDF]
Cancers (Basel)Papaioannou O +9 more
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Noninvasive monitoring and prediction of cell count of Saccharomyces suspensions using ultrasonic measurements and artificial neural networks. [PDF]
Anal Bioanal ChemGeier D +3 more
europepmc +1 more source
SOME DIFFERENTIAL COUNTS OF THE CELLS IN THE LYMPH OF THE DOG: THEIR BEARING ON PROBLEMS IN HÆMATOLOGY [PDF]
, 1908 F. Peyton Rous
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