Results 151 to 160 of about 5,958,944 (301)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Investigating single-cell growth of microbial cell factories: is counting cells enough?

, 2014
Helfrich S, Grünberger A, Kohlheyer D, Wiechert W, Nöh K. Investigating single-cell growth of microbial cell factories: is counting cells enough?
Kohlheyer, Dietrich, Nöh, Katharina, Wiechert, Wolfgang, Grünberger, Alexander, Helfrich, Stefan   +4 more
core  

ACCT is a fast and accessible automatic cell counting tool using machine learning for 2D image segmentation. [PDF]

Sci Rep, 2023
Kataras TJ, Jang TJ, Koury J, Singh H, Fok D, Kaul M.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cell counting and velocity algorithms for hydrodynamic study of unsteady biological flows in micro-channels. [PDF]

Biomicrofluidics, 2023
Torrisi F, Stella G, Guarino FM, Bucolo M.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

DeepD&Cchl: an AI tool for automated 3D single-cell chloroplast detection, counting, and cell type clustering

Chloroplast density in cells varies among different types of cells and plants. In current single-cell spatiotemporal analysis, the automatic detection and quantification of chloroplasts at the single-cell level is crucial.
Qiong Zhao, Qun Su, Shaokai Yang, Ningjing Liu, Huaying Wang, Zhengsheng Hu, Xinyi Liao, Feng Li, Qiuqi Guo, Tao Wang, Zhao Dong, Yan Sha, Le Liu   +12 more
core   +1 more source

Epigenetic Immune Cell Counting to Analyze Potential Biomarkers in Preterm Infants: A Proof of Principle in Necrotizing Enterocolitis. [PDF]

Int J Mol Sci, 2023
Schoenaker MHD, Zuiderwijk MO, Bekker V, Bredius RGM, Werner J, Schulze JJ, van der Burg M, Blom M.   +7 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

SAU-Net: A Unified Network for Cell Counting in 2D and 3D Microscopy Images. [PDF]

IEEE/ACM Trans Comput Biol Bioinform, 2022
Guo Y, Krupa O, Stein J, Wu G, Krishnamurthy A.   +4 more
europepmc   +1 more source