Results 151 to 160 of about 3,569,220 (384)
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
The Measurement of the Opacity of Bacterial Cultures with a Photo-Electric Cell [PDF]
, 1933 Tikvah Alper, Max Sterne
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Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Cultural Shift or Linguistic Drift? Comparing Two Computational Measures of Semantic Change [PDF]
arXiv, 2016 Words shift in meaning for many reasons, including cultural factors like new technologies and regular linguistic processes like subjectification. Understanding the evolution of language and culture requires disentangling these underlying causes. Here we show how two different distributional measures can be used to detect two different types of semantic
arxiv
The Measurement of Proliferation in Tissue Cultures by Enumeration of Cell Nuclei [PDF]
, 1951 Katherine K. Sanford +4 more
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Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice [PDF]
, 2006 Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. Expression of PS1 mutations in cell culture systems and in primary neurons from transgenic mice increases their vulnerability to cell ...
Czech, Christian +6 more
core
Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
Molecular Oncology, EarlyView.NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi +5 more
wiley +1 more source
Therapeutic potential and action mechanisms of licochalcone B: a mini review
Frontiers in Molecular BiosciencesLicochalcone B (LicB), a chalcone derived from Glycyrrhiza uralensis and Glycyrrhiza glabra, has received considerable attention due to its diverse pharmacological properties.
Sibhghatulla Shaikh +7 more
doaj +1 more source
THE FORM OF THE EPITHELIAL CELLS IN CULTURES OF FROG SKIN, AND ITS RELATION TO THE CONSISTENCY OF THE MEDIUM [PDF]
, 1915 Eduard Uhlenhuth
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