Results 151 to 160 of about 3,334,633 (288)

Comparing intra-uterine injection of mononuclear cells and platelet-rich plasma on the pregnancy rate of women with recurrent implantation failure: An RCT

International Journal of Reproductive BioMedicine
Background: Recurrent implantation failure (RIF) can be explained mainly by improper crosstalk between the embryo and endometrium. The T-helper1/T-helper2 profile balance influences effective embryo implantation.
Hoda Fazaeli, Azar Sheikholeslami, Zahra Ebrahimi, Naser Kalhor, Leila Naserpour   +4 more
doaj   +1 more source

Multi-Scale Kinetics Modeling for Cell Culture Process with Metabolic State Transition [PDF]

arXiv
To advance the understanding of cellular metabolisms and control batch-to-batch variations in cell culture processes, a multi-scale mechanistic model with a bottom-up and top-down structure was developed to simulate the dynamics of cell culture process undergoing metabolic state transitions. This model integrates interactions at the molecular, cellular,
arxiv  

Remote Cell Growth Sensing Using Self-Sustained Bio-Oscillations [PDF]

, 2018
A smart sensor system for cell culture real-time supervision is proposed, allowing for a significant reduction in human effort applied to this type of assay. The approach converts the cell culture under test into a suitable “biological” oscillator.
Daza Navarro, María Paula, Huertas Sánchez, Gloria, Maldonado-Jacobi, Andrés, Martín Rubio, María Esther, Olmo Fernández, Alberto, Pérez García, Pablo, Rueda Rueda, Adoración (Coordinador), Serrano Viseas, Juan Alfonso, Sánchez Aguayo, Inmaculada (Coordinador), Yúfera García, Alberto   +9 more
core  

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Identification of cellular signatures associated with chinese hamster ovary cell adaptation for secretion of antibodies

Computational and Structural Biotechnology Journal
The secretory capacity of Chinese hamster ovary (CHO) cells remains a fundamental bottleneck in the manufacturing of protein-based therapeutics. Unconventional biological drugs with complex structures and processing requirements are particularly ...
Ying Bai, Ivan Domenech Mercadé, Ramy Elgendy, Giulia Lambiase, Sew Peak-Chew, Catarina Franco, Steven W. Wingett, Tim J. Stevens, Luigi Grassi, Noah Hitchcock, Cristina Sayago Ferreira, Diane Hatton, Elizabeth A. Miller, Rajesh K. Mistry   +13 more
doaj  

Multiplex single‐cell profiling of putative cancer stem cell markers ALDH1, SOX9, SOX2, CD44, CD133 and CD15 in endometrial cancer

Molecular Oncology, EarlyView.
Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien, Marta E. Hjelmeland, Hege F. Berg, Rose M. Gold, Kathrine Woie, Lars A. Akslen, Ingfrid S. Haldorsen, Camilla Krakstad   +7 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Ultraviolet microscopy aids in cytological and biomedical research [PDF]

, 1967
Ultraviolet microscopy is used by cytologists and biochemists to study the morphological and physiological changes in the living cell under varied culture conditions.
Schlenk, F., Svihla, B.
core   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Detection of novel PPP1R1B::STARD3 fusion transcript in acute myeloid leukemia: a case report

Journal of Medical Case Reports
Background Acute myeloid leukemia (AML) is the second most common type of leukemia in children. Although prognostic and diagnostic tests of AML patients have improved, there is still a great demand for new reliable clinical biomarkers for AML.
Elahe Dehghani Firouzabadi, Mohammed Allami, Eman Jassim Mohammed, Hossein Barzegar, Mahtab Dastpak, Reza Alemohammad, Vahid Moghimi, Reihaneh Alsadat Mahmoudian, Fatemeh Nasrabadi, Nahid Arghiani, Yohei Kitamura, Seyed Abolfazl Hosseini, Ali Ghasemi, Moein Farshchian   +13 more
doaj   +1 more source