Results 51 to 60 of about 10,542,794 (310)

Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies

Frontiers in Cell and Developmental Biology, 2020
The introduction of advanced therapy medicinal products (ATMPs) to the global pharma market has been revolutionizing the pharmaceutical industry and has opened new routes for treating various types of cancers and incurable diseases.
Roya Ramezankhani, Roya Ramezankhani, Shukoofeh Torabi, Shukoofeh Torabi, Neda Minaei, Neda Minaei, Hoda Madani, Hoda Madani, Siamak Rezaeiani, Siamak Rezaeiani, Seyedeh Nafiseh Hassani, Seyedeh Nafiseh Hassani, Adrian P. Gee, Massimo Dominici, Daniela Nascimento Silva, Daniela Nascimento Silva, Hossein Baharvand, Hossein Baharvand, Hossein Baharvand, Ensiyeh Hajizadeh-Saffar, Ensiyeh Hajizadeh-Saffar, Ensiyeh Hajizadeh-Saffar   +21 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

FOXO3a/PI3K/Akt pathway participates in the ROS- induced apoptosis triggered by α-ZEL and β-ZEL

Scientific Reports
Zearalenone (ZEN), an estrogenic mycotoxin, is one of the most common food and feed contaminants. Also, its metabolites α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL) are considered to induce oxidative stress, however its effect in prostate cells is not ...
Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Kinga Anna Urbanek, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska   +4 more
doaj   +1 more source

Extracellular matrix of lung scaffolds submitted to different means of sterilization: a systematic review [version 1; peer review: 1 approved, 2 approved with reservations]

F1000Research
Chronic respiratory diseases often necessitate lung transplantation due to irreversible damage. Organ engineering offers hope through stem cell-based organ generation. However, the crucial sterilization step in scaffold preparation poses challenges. This
Luis Vicente Franco Oliveira, Giuseppe Insalaco, Renata K. Palma, Rodolfo P. Vieira, Deise A. A. P. Oliveira, Rodrigo F. Oliveira, Iransé Oliveira-Silva, Miria C. Oliveira, Diego A. C. P. G. Mello, Andressa D. Cereta, Adriano L. Fonseca, Joao Pedro R. Afonso, Ricardo S. Moura   +12 more
doaj   +1 more source

Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem Cells

Cells, 2021
Mesenchymal stem cells (MSCs) are of great interest for their use in cell-based therapies due to their multipotent differentiation and immunomodulatory capacities.
Ilias Nikolits, Sabrina Nebel, Dominik Egger, Sebastian Kreß, Cornelia Kasper   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Novel 3D-Printed Cell Culture Inserts for Air–Liquid Interface Cell Culture

, 2022
In skin research, widely used in vitro 2D monolayer models do not sufficiently mimic physiological properties. To replace, reduce, and refine animal experimentation in the spirit of ‘3Rs’, new approaches such as 3D skin equivalents (SE) are needed to ...
Marvin Corea, Magdalena Metzger, Schädl, Barbara, Grillari, Johannes, Dungel, Peter, Peter Dungel, Johannes Grillari, Bauer, Magdalena, Barbara Schädl, Metzger, Magdalena, Corea, Marvin, Magdalena Bauer   +11 more
core   +1 more source