Results 311 to 320 of about 3,157,910 (364)

Unsupervised non‐small cell lung cancer tumor segmentation using cycled generative adversarial network with similarity‐based discriminator

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background Tumor segmentation is crucial for lung disease diagnosis and treatment. Most existing deep learning‐based automatic segmentation methods rely on manually annotated data for network training. Purpose This study aims to develop an unsupervised tumor segmentation network smic‐GAN by using a similarity‐driven generative adversarial ...
Chengyijue Fang   +2 more
wiley   +1 more source

Demonstration of an enhanced dosing pattern for debulking large and bulky unresectable tumors via differential hole‐size spatially fractionated radiotherapy

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose/objective We propose a novel lattice deployment for spatially fractionated radiotherapy (SFRT) treatments. In this approach, a larger diameter high‐dose sphere is centrally placed in the bulky tumor mass and surrounded by smaller diameter high‐dose spheres.
Joshua Misa   +2 more
wiley   +1 more source

Down‐modulation of CD4 antigen during programmed cell death in U937 cells

open access: bronze, 1993
Walter Malorni   +5 more
openalex   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra   +17 more
wiley   +1 more source

Apoptotic Cell Death Induced by Anti-IgM Antibody and Phorbol Esters Is Inhibited by Interleukin-4 in Human B Lymphoma Cell Line MBC-1

open access: bronze, 1994
Yoshihiro Komada   +6 more
openalex   +1 more source

HPDL Variant Type Correlates With Clinical Disease Onset and Severity

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee   +19 more
wiley   +1 more source

ADAPT NXT: Fixed Cycles or Every‐Other‐Week IV Efgartigimod in Generalized Myasthenia Gravis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This phase 3b, open‐label, randomized ADAPT NXT study investigated the efficacy, safety, and tolerability of efgartigimod administered in either a fixed cycles dosing regimen (3 cycles of 4 once‐weekly infusions, with 4 weeks between cycles) or a cycle followed by every‐other‐week (Q2W) dosing.
Ali A. Habib   +16 more
wiley   +1 more source

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