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Cell Death | Cell Death by Apoptosis and Necrosis
2021Various genetically encoded programs involved in the signaling, initiation, and execution of cell death decide cells׳ fate during development and adult life. These programs can execute physiological cell death during development or tissue turnover, and are also involved in the inappropriate elimination of cells under pathological conditions.
Ermer, Veronika +2 more
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Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2004
HMGB1, a very mobile chromatin protein, leaks out from necrotic cells and signals to neighbouring cells that tissue damage has occurred. At least one receptor for extracellular HMGB1 exists, and signals to different cells to divide, migrate, activate inflammation or start an immune response.
BIANCHI, MARCO EMILIO +1 more
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HMGB1, a very mobile chromatin protein, leaks out from necrotic cells and signals to neighbouring cells that tissue damage has occurred. At least one receptor for extracellular HMGB1 exists, and signals to different cells to divide, migrate, activate inflammation or start an immune response.
BIANCHI, MARCO EMILIO +1 more
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Chapter Eleven Granzymes and Cell Death
2008Granzymes are cell death-inducing serine proteases released from cytotoxic granules of cytotoxic T lymphocytes and natural killer cells during granule exocytosis in response to viral infection or against transformed cells marked for elimination. A critical cofactor for the granule exocytosis pathway is perforin, which mediates the entry of granzymes ...
Martinvalet, Denis +2 more
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Blocking cell death to enhance cell death
Science Translational Medicine, 2017Inhibiting caspase activation during apoptosis may enhance the ability of the immune system to target cancer cells.
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2016
IAPs were named as inhibitors of apoptosis, programmed cell death, but it has become apparent that they are regulators of other types of cell death too. Because they inhibit cell death in cancer cells there has been an intense interest in developing inhibitors of these proteins to induce or sensitise cancer cells to death.
James E Vince, John Silke
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IAPs were named as inhibitors of apoptosis, programmed cell death, but it has become apparent that they are regulators of other types of cell death too. Because they inhibit cell death in cancer cells there has been an intense interest in developing inhibitors of these proteins to induce or sensitise cancer cells to death.
James E Vince, John Silke
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Retrodifferentiation and Cell Death
Critical Reviews™ in Oncogenesis, 1994The reversibility of a differentiation program termed dedifferentiation, redifferentiation, or retrodifferentiation opens a spectrum of new possibilities for cellular development. During differentiation and retrodifferentiation, the expression of gene products associated with a differentiated phenotype and cell cycle regulation demonstrate inverse ...
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Programmed Cell Death or Cell Death Programme? That is the Question
Journal of Theoretical Biology, 2001Sylvie Boisseau +4 more
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