Results 301 to 310 of about 12,907,435 (362)
Some of the next articles are maybe not open access.
1987
All lymphocytes are derived from an unidentified multipotent precursor (Fig. 10.1). T cell precursors migrate from the liver and bone marrow in fetal life and from the bone marrow in adult life, to the thymus. It is unknown whether the stem cells become committed to T cell differentiation before or after they have entered the thymus.
Anthony S-Y. Leong, Ian J. Forbes
openaire +3 more sources
All lymphocytes are derived from an unidentified multipotent precursor (Fig. 10.1). T cell precursors migrate from the liver and bone marrow in fetal life and from the bone marrow in adult life, to the thymus. It is unknown whether the stem cells become committed to T cell differentiation before or after they have entered the thymus.
Anthony S-Y. Leong, Ian J. Forbes
openaire +3 more sources
Osteoblastic cells: Differentiation and trans-differentiation
Archives of Biochemistry and Biophysics, 2008The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that ...
Kassem, Moustapha +2 more
openaire +3 more sources
T cell differentiation in the thymus
Cytotechnology, 1991T lymphocytes arise in the thymus and seed to peripheral lymphoid organs as fully functional cells at the time of exit. In humans, the thymus begins to function very early in ontogeny and releases large numbers of T cells before the time of birth. However, the vast majority of developing thymocytes (>95%) die within the thymus as a result of stringent ...
Carlo E. Grossi +3 more
openaire +3 more sources
Science's STKE, 2006
This 3-week-long series of collaborative laboratory exercises explores how to use a cultured cell system (PC12 cells) to study signaling pathways involved in cellular differentiation. The laboratory would be useful in a neurobiology or cell biology course for advanced undergraduate students.
Jay A. Blundon +2 more
openaire +2 more sources
This 3-week-long series of collaborative laboratory exercises explores how to use a cultured cell system (PC12 cells) to study signaling pathways involved in cellular differentiation. The laboratory would be useful in a neurobiology or cell biology course for advanced undergraduate students.
Jay A. Blundon +2 more
openaire +2 more sources
Cell Differentiation and Malignancy
Cell Biophysics, 1986An understanding of the mechanism that controls growth and differentiation in normal cells would seem to be an essential requirement to elucidate the origin and reversibility of malignancy. For this approach I have mainly used normal and leukemic blood cells, and in most studies have used myeloid blood cells as a model system.
openaire +3 more sources
Extrathymic T cell differentiation
Current Opinion in Immunology, 1995In the mouse, the gut mucosa is a major site of extrathymic differentiation of T cells. Recent data in this past year show that this process differs from the main thymic differentiation pathway not only in its location, but also in its use of costimulatory molecules, signal transduction modules, and mechanisms of repertoire selection. The thymus exerts
Delphine Guy-Grand +2 more
openaire +3 more sources
Glycolipids and Cell Differentiation
1980Differentiation of a cultured cell refers generally to a change in the expression of some peculiar functions specific to this cell. Generally differentiation involves only a modification of some biochemical properties of the cell such as synthesis of melanin by melanocytes (KREIDER et al., 1975) or synthesis of collagen by bone fibroblasts (MANNER and ...
Paul Mandel, Jacques Robert, G. Rebel
openaire +3 more sources
Erythroid cell differentiation
Molecular and Cellular Biochemistry, 1978Normal and transformed erythroid cell precursors provide the opportunity for study of a number of problems relevant to the regulation of proliferation and differentiation in a developmental system. Evidence is presented which suggests that the hormone, erythropoietin, has a primary role in regulating precursor cell proliferation.
Richard A. Rifkind +2 more
openaire +3 more sources
Differentiation of Human T Cells
Clinics in Laboratory Medicine, 1988This article discusses the ontogeny of human T cells along with the relationship of normal T-cell maturation to the development of various malignant T-cell syndromes. The impact of monoclonal antibody technology, the discovery of the T-cell receptor for antigen, and the discovery of mechanisms of thymocyte-thymic microenvironment interactions on the ...
Barton F. Haynes, Stephen M. Denning
openaire +3 more sources
Synchronous Cell Differentiation
1968Publisher Summary Synchronous cell differentiation refers to the occurrence of simultaneous cellular transformations throughout a population of cells. Although the induction of cell division synchrony may be a prerequisite for such an experimental situation, it need not be the primary concern of the investigator.
Ivan L. Cameron +3 more
openaire +3 more sources