Results 111 to 120 of about 12,032,873 (351)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sup. Figure 3: Foretinib and nintedanib inhibited the TRK-A in the kinase inhibition profile assay. from Foretinib Overcomes Entrectinib Resistance Associated with the <i>NTRK1</i> G667C Mutation in <i>NTRK1</i> Fusion–Positive Tumor Cells in a Brain Metastasis Model

, 2023
Akihiro Nishiyama, Tadaaki Yamada, Kenji Kita, Rong Wang, Sachiko Arai, Koji Fukuda, Azusa Tanimoto, Shinji Takeuchi, Shoichiro Tange, Atsushi Tajima, Noritaka Furuya, Takayoshi Kinoshita, Seiji Yano   +12 more
openalex   +1 more source

A novel human endogenous retroviral protein inhibits cell-cell fusion

Scientific Reports, 2013
While common in viral infections and neoplasia, spontaneous cell-cell fusion, or syncytialization, is quite restricted in healthy tissues. Such fusion is essential to human placental development, where interactions between trophoblast-specific human ...
J. Sugimoto, Makiko Sugimoto, H. Bernstein, Y. Jinno, D. Schust   +4 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

An Attempt at Fusing Primordial Germ Cell with Embryonic Blood Cell in Chickens Using Inactivated Sendai Virus or Electrical Stimulation

The Journal of Poultry Science, 2005
In order to produce nuclear transferred PGCs, fusion of primordial germ cell (PGC) with embryonic blood cell (EBC) was attempted. PGCs and EBCs were isolated from the blood of stages 13-15 embryos.
Mitsuru Naito, Takashi Harumi, Yuko Matsubara, Takashi Kuwana   +3 more
doaj   +1 more source

A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasia resulting in a fusion of IGL and CCND1: case report [PDF]

, 2011
Cristiano Krings Rocha, Inka Praulich, Iris Gehrke, Michael Hallek, Karl‐Anton Kreuzer   +4 more
openalex   +1 more source

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

PLoS Pathogens, 2013
LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50≤0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic ...
Frédéric Vigant, Jihye Lee, A. Hollmann, L. Tanner, Zeynep Akyol Ataman, T. Yun, G. Shui, Hector C. Aguilar, Dong Zhang, D. Meriwether, G. Roman-Sosa, Lindsey R. Robinson, Terry L Juelich, Hubert Buczkowski, S. Chou, M. Castanho, M. Wolf, Jennifer K. Smith, A. Banyard, M. Kielian, S. Reddy, M. Wenk, M. Selke, N. Santos, Alexander N. Freiberg, M. Jung, Benhur Lee   +26 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1 [PDF]

, 1995
S Frey, Mark Marsh, Sarah Günther, Annegret Pelchen–Matthews, Paul E. Stephens, SUE ORTLEPP, Thomas Stegmann   +6 more
openalex   +1 more source