Results 141 to 150 of about 12,374,157 (394)

Cell fusion induced by ERVWE1 or measles virus causes cellular senescence

Genes & Development, 2013
Cellular senescence limits proliferation of potentially detrimental cells, preventing tumorigenesis and restricting tissue damage. However, the function of senescence in nonpathological conditions is unknown.
A. Chuprin, Hilah Gal, T. Biron-Shental, Anat Biran, A. Amiel, S. Rozenblatt, V. Krizhanovsky   +6 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Therapeutic cell fusion

British Journal of Surgery, 2005
Abstract This article continues the Journal's 2005 series of leaders highlighting areas where laboratory science meets clinical practice. In it Dr Holger Willenbring of the Oregon Stem Cell Center discusses the promise of therapeutic cell fusion and the difficulties that remain in bringing this technique into clinical practice.
openaire   +3 more sources

Syncytin 1, CD9, and CD47 regulating cell fusion to form PGCCs associated with cAMP/PKA and JNK signaling pathway

Cancer Medicine, 2019
Background We have previously reported the formation of polyploid giant cancer cells (PGCCs) through endoreduplication or cell fusion after cobalt chloride (CoCl2) induction. Cell fusion plays an important role in development and disease.
Fei Fei, Chunyuan Li, Xinlu Wang, Jiaxing Du, Kai Liu, Bo Li, Peiyu Yao, Yuwei Li, Shiwu Zhang   +8 more
doaj   +1 more source

Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction

mBio, 2019
Dendritic cells (DCs) and macrophages as well as osteoclasts (OCs) are emerging as target cells of HIV-1 involved in virus transmission, dissemination, and establishment of persistent tissue virus reservoirs. While these myeloid cells are poorly infected
Maorong Xie, Héloïse Leroy, Rémi Mascarau, Marie Woottum, Maeva Dupont, Camille Ciccone, Alain Schmitt, Brigitte Raynaud-Messina, Christel Vérollet, Jérôme Bouchet, Lucie Bracq, Serge Benichou   +11 more
doaj   +1 more source

Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells [PDF]

, 1996
To investigate the role that aging-dependent accumulation of mitochondrial DNA (mtDNA) mutations plays in the senescence processes, mitochondria from fibroblasts of 21 normal human individuals between 20 weeks (fetal) and 103 years of age were introduced
Attardi, Giuseppe, Bresolin, Nereo, Laderman, Kenneth A., Mazzucchelli, Franca, Penny, James R., Scarlato, Guglielmo   +5 more
core   +1 more source

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

PLoS Pathogens, 2013
LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50≤0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic ...
Frédéric Vigant, Jihye Lee, A. Hollmann, L. Tanner, Zeynep Akyol Ataman, T. Yun, G. Shui, Hector C. Aguilar, Dong Zhang, D. Meriwether, G. Roman-Sosa, Lindsey R. Robinson, Terry L. Juelich, Hubert Buczkowski, S. Chou, M. Castanho, M. Wolf, Jennifer K. Smith, A. Banyard, M. Kielian, S. Reddy, M. Wenk, M. Selke, N. Santos, Alexander N. Freiberg, M. Jung, Benhur Lee   +26 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A novel human endogenous retroviral protein inhibits cell-cell fusion

Scientific Reports, 2013
While common in viral infections and neoplasia, spontaneous cell-cell fusion, or syncytialization, is quite restricted in healthy tissues. Such fusion is essential to human placental development, where interactions between trophoblast-specific human ...
J. Sugimoto, Makiko Sugimoto, H. Bernstein, Y. Jinno, D. Schust   +4 more
semanticscholar   +1 more source