Metabolic Consequences of Rheumatoid Arthritis
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry+2 more
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Monocyte-cancer cell fusion is mediated by phosphatidylserine-CD36 receptor interaction and induced by ionizing radiation. [PDF]
Shabo I+3 more
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Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib
Objective Patients with rheumatoid arthritis (RA) often fail to respond to therapies, including JAK inhibitors (JAKi), and treatment allocation is made via a trial‐and‐error strategy. A comprehensive analysis of responses to JAKi, including tofacitinib, by RNA sequencing (RNAseq) would allow the discovery of transcriptomic markers with a two‐fold ...
Chiara Bellocchi+11 more
wiley +1 more source
Syncytin and Cancer Cell Fusions [PDF]
Larsson, Lars-Inge+3 more
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Separate, separated, and together: the transcriptional program of the <i>Clostridium acetobutylicum-Clostridium ljungdahlii</i> syntrophy leading to interspecies cell fusion. [PDF]
Willis NB, Papoutsakis ET.
europepmc +1 more source
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe+4 more
wiley +1 more source
TFEB controls expression of human syncytins during cell-cell fusion. [PDF]
Esbin MN+6 more
europepmc +1 more source
A novel function for the sperm adhesion protein IZUMO1 in cell-cell fusion. [PDF]
Brukman NG+6 more
europepmc +1 more source
Failure to cleave measles virus fusion protein in lymphoid cells. A possible mechanism for viral persistence in lymphocytes [PDF]
Ryo Fujinami, MBA Oldstone
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