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Fusion of T and B cells

Somatic Cell Genetics, 1977
Hybrid cells were prepared by fusin an immunoglobulin-secreting mouse myeloma lin e (B cell) with an allogenic T-cell lymphoma which expresses the surface antigen Thy 1. The resulting hybrids expressed H2 antigens of both parental cells and secreted the immunoblobulin of the myeloma parent but did not express the Thy 1 antigen of the lymphoma parent ...
Kohler, G, Pearson, T, Milstein, C
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Chemotropism and Cell-Cell Fusion in Fungi

Microbiology and Molecular Biology Reviews, 2022
Fungi exhibit an enormous variety of morphologies, including yeast colonies, hyphal mycelia, and elaborate fruiting bodies. This diversity arises through a combination of polar growth, cell division, and cell fusion.
Manuella R. Clark-Cotton   +2 more
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The mechanism of cell-cell fusion

Trends in Biochemical Sciences, 1979
Abstract Three stages are involved in cell-cell fission mediated by viruses and chemicals: (1) agglutination; (2) membrane fusion between adjacent cells; and (3) osmotic swelling. The recogni tion that stages (2) and (3) are separate events has led to a better understanding of the overall process.
Charles A. Pasternak, S. Knutton
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Cell-Cell Fusion

Science, 2012
Cell Biology![Figure][1] CREDIT: TSUKASA OIKAWA Osteoclasts are cells that promote bone remodeling, and their hyperactivity is linked to bone-destructive disorders, including osteoporosis. Activated osteoclast precursors develop columnar actin structures, known as podosomes, which are similar to the invadopodia observed in invasive cancer cells ...
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Unveiling the Mechanisms of Cell-Cell Fusion

Science, 2005
Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and ...
Eric N. Olson   +2 more
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Methodologies in the Study of Cell–Cell Fusion

Methods, 1998
The process of membrane fusion has been profitably studied by fusing cells that express fusion proteins on their surfaces to the membranes of target cells. Primary methods for monitoring the occurrence of fusion between cells are measurement of formation of heterokaryons, measurement of activation of reporter genes, measurement of transfer of lipidic ...
Grigory B. Melikyan, Fredric S. Cohen
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Mechanisms of cell fusion

Nature, 1975
WE report new findings on the chemically-induced fusion of hen erythrocytes and discuss possible ways in which the lipid and protein/glycoprotein components of membranes may behave during the process of membrane fusion. Our observations are consistent with Poste and Allison's1 idea that the aggregation of intrinsic membrane proteins is important in ...
Jack A. Lucy   +3 more
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Lysolecithin and Cell Fusion

Nature, 1970
Lysolecithin will induce cell fusion in several different types of cell, and both multinucleated syncytia and heterokaryons can be formed.
A. R. Poole, J. A. Lucy, J. I. Howell
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ADAMs and cell fusion

Current Opinion in Cell Biology, 1996
Members of the ADAM family (membrane proteins with a disintegrin and metalloprotease domain) have been implicated in several cell-interactive events, including cell-cell fusion. Recent evidence implicates three ADAMs, fertilin-alpha, fertilin-beta, and meltrin-alpha, in sperm-egg fusion and myoblast fusion.
Ari Pekka J Huovila   +2 more
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Signal for cell fusion

Nature, 1976
THE mating of the gametes of Ulva mutabilis1 occurs essentially as described for Chlamydomonas2,3 When the gametes are mixed, they cluster and agglutinate with the tips of their flagella. Pairs consisting of a (+) and (−)-gamete leave the cluster, the cell bodies are brought together and fusion initiated.
Arne Løvlie, Eva Bryhni
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