Results 51 to 60 of about 762,610 (162)
Abstract This article continues the Journal's 2005 series of leaders highlighting areas where laboratory science meets clinical practice. In it Dr Holger Willenbring of the Oregon Stem Cell Center discusses the promise of therapeutic cell fusion and the difficulties that remain in bringing this technique into clinical practice.
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Castanea mollissima Bl. is rich in nutrition and strong in stress resistance, and has nutritional, economic, and ecological values. A protoplast is impactful in somatic fusion and germplasm creation.
Shiying Zhang, Sujuan Guo, Ruijie Zheng
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The HIV-1 entry pathway into permissive cells has been a subject of debate. Accumulating evidence, including our previous single virus tracking results, suggests that HIV-1 can enter different cell types via endocytosis and CD4/coreceptor-dependent ...
Mariana Marin +4 more
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Two cellular models for analyzing mitochondrial heteroplasmy [PDF]
Aim: Mitochondria are essential for brain development, and the presence of different mitochondrial types is called mitochondrial heteroplasmy. Mitochondrial dysfunction is a central aspect of many people’s neurological diseases.
Yaning Hu +3 more
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A novel fusogenic herpes simplex virus for oncolytic virotherapy of squamous cell carcinoma
Background R849 is a neurovirulent γ134.5 gene-deficient form of herpes simplex virus type 1 (HSV-1) and has LacZ genes at the deleted sites of the γ134.5 gene. HF is a spontaneously occurring, fusogenic HSV-1 strain.
Iwai Soichi +5 more
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Cell-to-cell communication and cell fusion are fundamental biological processes across the tree of life. Survival is often dependent upon being able to identify nearby individuals and respond appropriately.
Monika S. Fischer +2 more
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The First Family of Cell-Cell Fusion [PDF]
Our understanding of the developmentally critical process of cell-cell fusion has been greatly advanced by the identification of the first family of cell-cell fusion proteins. Together, the two founding members of the FF family execute the majority of cell-cell fusion events in C. elegans.
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Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction
Dendritic cells (DCs) and macrophages as well as osteoclasts (OCs) are emerging as target cells of HIV-1 involved in virus transmission, dissemination, and establishment of persistent tissue virus reservoirs. While these myeloid cells are poorly infected
Maorong Xie +11 more
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Cell Fusion in Malignancy: A Cause or Consequence? A Provocateur or Cure?
Cell fusion has been observed in malignancy, and cancer cells have been found especially apt to fuse with other cells. Investigation of human and experimental malignancies suggests spontaneous fusion of normal cells can induce manifold genetic changes ...
Jeffrey L. Platt, Marilia Cascalho
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