Results 61 to 70 of about 6,470,185 (304)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion

eLife, 2020
Cell-cell fusion, which is essential for tissue development and used by some viruses to form pathological syncytia, is typically driven by fusogenic membrane proteins with tall (>10 nm) ectodomains that undergo conformational changes to bring apposing
Ka Man Carmen Chan, Sungmin Son, Eva M Schmid, Daniel A Fletcher   +3 more
doaj   +1 more source

“Keep on rolling”: circulating cells in a botryllid ascidian torpor

Frontiers in Ecology and Evolution, 2023
Hemocytes of the colonial tunicate Botrylloides leachii play important roles throughout the animal’s life span, including transport and storage of nutrients, respiration, regeneration, budding, sexual reproduction, defense responses, and tunic generation.
Yosef Hyams, Yosef Hyams, Julia Panov, Elizaveta Taranenko, Leonid Brodsky, Yuval Rinkevich, Baruch Rinkevich   +6 more
doaj   +1 more source

Mycobacterium tuberculosis antigen 85B and ESAT-6 expressed as a recombinant fusion protein in Mycobacterium smegmatis elicits cell-mediated immune response in a murine vaccination model [PDF]

, 2013
This is the post-print version of the final paper published in Molecular Immunology. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting ...
Kishore, U, Leiva, S, Robertson, BD, Rosenkrands, I, Nagy, J, Tsolaki, AG   +5 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Monoclonal Antibody against Porcine LAG3 Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection

Veterinary Sciences
Lymphocyte activation gene 3 (LAG3) is an inhibitory receptor and the interaction between fibrinogen-like protein 1 and LAG3 can inhibit the anti-tumor effect of T cells both in vivo and in vitro, which was regarded as a new immune evasion mechanism ...
Hui Wang, Xu Zheng, Danyang Zheng, Xiaoqian Wang, Zhiqian Zhao, Mi Zhao, Qiang Guo, Yang Mu   +7 more
doaj   +1 more source

Neurospora crassa NADPH Oxidase NOX-1 Is Localized in the Vacuolar System and the Plasma Membrane

Frontiers in Microbiology, 2019
The NADPH oxidases (NOX) catalyze the production of superoxide by transferring electrons from NADPH to O2, in a regulated manner. In Neurospora crassa NOX-1 is required for normal growth of hyphae, development of aerial mycelium and asexual spores, and ...
Nallely Cano-Domínguez, Barry Bowman, Leonardo Peraza-Reyes, Jesús Aguirre   +3 more
doaj   +1 more source

Rapid regulation of protein activity in fission yeast [PDF]

, 2014
Background: The fission yeast Schizosaccharomyces pombe is widely-used as a model organism for the study of a broad range of eukaryotic cellular processes such as cell cycle, genome stability and cell morphology. Despite the availability of extensive set
Sharom, Jeffrey R., Boe, Cathrine A., Tyers, Michael D., Boye, Erik, Kearsey, Stephen, MacNeill, Stuart Andrew, Pai, Chen-Chun, Skjolberg, Henriette C., Grallert, Beata, Garcia, Ignacio   +9 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Workshop at Data and Planning Center of NIFS in 2003 "Assesment of Fusion R&D" - The Critical Issues of Demonstration Fusion Reactor - [PDF]

, 2004
実証炉を構想しそれに至る課題を整理することは、核融合研究開発の現状を評価するうえで最も適切な作業のひとつと考えた。磁場閉じ込めと慣性閉じ込め核融合に共通な課題は経済性の改善である。また、磁場閉じ込めではトカマクもヘリカルも将来性のあるダイバータの開発は共通である。 経済性に関しては先進トカマクや高速点火方式のレーザ慣性核融合の提案が出てきている。さらにダイバータに関しては可動型や外置き型の研究が進められている。これらの要約は添付した。In order to asses the fusion ...
TAZIMA, Teruhiko, TAJIMA, Teruhiko, IGUCHI, Harukazu   +2 more
core