Results 91 to 100 of about 599,693 (212)

MECHANISMS OF DISEASE Acute Oxygen-Sensing Mechanisms [PDF]

, 2005
JOSEPH PRIESTLEY, ONE OF THE THREE SCIENTISTS CREDITED WITH THE discovery of oxygen, described the death of mice that were deprived of oxygen. However, he was also well aware of the toxicity of too much oxygen, stating, “For as a candle burns much faster
Buckler, Keith J., E. Kenneth Weir, M.D., López Barneo, José, Stephen L. Archer, M.D   +3 more
core  

Hypoxic Cell Waves around Necrotic Cores in Glioblastoma: A Biomathematical Model and its Therapeutic Implications

, 2012
Glioblastoma is a rapidly evolving high-grade astrocytoma that is distinguished pathologically from lower grade gliomas by the presence of necrosis and microvascular hiperplasia.
Calvo, Gabriel F., Martínez-González, Alicia, Pérez-García, Víctor M., Romasanta, Luis A. Pérez   +3 more
core   +1 more source

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome [PDF]

, 2017
Background: Neuroblastoma is an aggressive childhood malignancy of the sympathetic nervous system. Despite multi-modal therapy, survival of high-risk patients remains disappointingly low, underscoring the need for novel treatment strategies.
Cannoodt, Robrecht, Claeys, Shana, De Preter, Katleen, Denecker, Geertrui, Durinck, Kaat, Kumps, Candy, Speleman, Franki   +6 more
core   +3 more sources

RANK-RANKL-OPG expression after gingival mesenchymal stem cell hypoxia preconditioned application in an orthodontic tooth movement animal model. [PDF]

J Oral Biol Craniofac Res, 2023
Nugraha AP, Ernawati DS, Narmada IB, Bramantoro T, Riawan W, Situmorang PC, Nam HY.   +6 more
europepmc   +1 more source

The role of hypoxia and complement receptor 2 or toll-like receptor 2 on B1 B cell effector function [PDF]

Master of ScienceDivision of BiologySherry D. FlemingProfessional phagocytes play a critical role in maintaining homeostasis within a host through phagocytic, microbicidal, and inflammatory activity.
Knights, Kaori
core   +1 more source

The Evolution of Cholesterol-Rich Membrane in Oxygen Adaption: The Respiratory System as a Model. [PDF]

, 2019
The increase in atmospheric oxygen levels imposed significant environmental pressure on primitive organisms concerning intracellular oxygen concentration management.
Patel, Hemal H, Zuniga-Hertz, Juan Pablo
core   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

Quantitative intravital imaging for real-time monitoring of pancreatic tumor cell hypoxia and stroma in an orthotopic mouse model. [PDF]

Sci Adv, 2023
Samuel T, Rapic S, O'Brien C, Edson M, Zhong Y, DaCosta RS.   +5 more
europepmc   +1 more source

CoCl2 simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis

Biological Research, 2019
Background/aims Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies.
Nishant Kumar Rana, Priya Singh, Biplob Koch   +2 more
doaj   +1 more source

CoCl₂-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors. [PDF]

Biomedicines, 2022
Kutryb-Zajac B, Kawecka A, Braczko A, Franczak M, Slominska EM, Giovannoni R, Smolenski RT.   +6 more
europepmc   +1 more source