Results 91 to 100 of about 11,093,569 (425)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Hypoxia modulates fibroblastic architecture, adhesion and migration: a role for HIF-1α in cofilin regulation and cytoplasmic actin distribution. [PDF]
PLoS ONE, 2013 Cells can adapt to hypoxia by various mechanisms. Yet, hypoxia-induced effects on the cytoskeleton-based cell architecture and functions are largely unknown.
Melanie Vogler +8 more
doaj +1 more source
Studies on the alternative evaluation of improving hypoxia tolerance function in health foods
Zhongguo shipin weisheng zazhi, 2023 ObjectiveTo explore the feasibility of new test methods for evaluation of improving hypoxia tolerance function in health food.MethodsHypoxia tolerance experiments were carried out on mice.
YANG Jun +6 more
doaj +1 more source
A mathematical study of the influence of hypoxia and acidity on the evolutionary dynamics of cancer [PDF]
arXiv, 2020 Hypoxia and acidity act as environmental stressors promoting selection for cancer cells with a more aggressive phenotype. As a result, a deeper theoretical understanding of the spatio-temporal processes that drive the adaptation of tumour cells to hypoxic and acidic microenvironments may open up new avenues of research in oncology and cancer treatment.
arxiv
Local and nonlocal phase-field models of tumor growth and invasion due to ECM degradation [PDF]
Math. Models Methods Appl. Sci. 29 (2019) 2433-2468, 2019 We present and analyze new multi-species phase-field mathematical models of tumor growth and ECM invasion. The local and nonlocal mathematical models describe the evolution of volume fractions of tumor cells, viable cells (proliferative and hypoxic cells), necrotic cells, and the evolution of MDE and ECM, together with chemotaxis, haptotaxis, apoptosis,
arxiv +1 more source
NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system [PDF]
, 2018 A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally.
Bogetti, María Eugenia +4 more
core +1 more source
Theranostics, 2021 Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, the mechanisms behind this resistance are still unclear.
Dongliang Wang +11 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells [PDF]
, 2014 Background: Hypoxia-induced genes are potential targets in cancer therapy. Responses to hypoxia have been extensively studied in vitro, however, they may differ in vivo due to the specific tumor microenvironment.
Gallé, B. (Birgit) +14 more
core +1 more source
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source