Glioblastoma, Cancer Stem Cells and Hypoxia
Brain Pathology, 2010 AbstractGlioblastoma (GBM) prognosis remains dismal, with most patients succumbing to disease within 1 or 2 years of diagnosis. Recent studies have suggested that many solid tumors, including GBM, are maintained by a subset of cells termed cancer stem cells (CSCs). It has been shown that these cells are inherently radio‐ and chemotherapy resistant, and
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The role of hypoxia in the maintenance of hematopoietic stem cells [PDF]
, 1993 MG Cipolleschi +2 more
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Cardiology Research and Practice, 2019 Objective. MiR-133b was dysregulated in myocardial infarction. However, the role and mechanism of miR-133b in myocardial infarction remains unclear.
Yongmei Zhou, Hui Huang, Xiaolin Hou
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CoCl2-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors. [PDF]
Biomedicines, 2022 Kutryb-Zajac B +6 more
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Improved oxygen release: an adaptation of mature red cells to hypoxia [PDF]
, 1968 Miles J. Edwards +3 more
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Earthing effects on mitochondrial function: ATP production and ROS generation
FEBS Open Bio, EarlyView.In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
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Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
Clinical and Translational Medicine, 2019 Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune cells including cytotoxic T cells; however ...
S. K. Daniel +3 more
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Radiation and chemotherapy variable response induced by tumor cell hypoxia: impact of radiation dose, anticancer drug, and type of cancer. [PDF]
Radiat Environ Biophys, 2022 Ibrahim AM +3 more
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Studies on Hypoxia: II. Autoradiographic Quantitation of Proline-3H Incorporation by Connective Tissue Cells of the Neonatal Hamster [PDF]
, 1968 D. Max Smith, Seong S. Han
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Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
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