Results 121 to 130 of about 349,615 (316)

Hypoxia Regulates Lymphoid Development of Human Hematopoietic Progenitors

Cell Reports, 2019
Summary: Hypoxia plays a major role in the physiology of hematopoietic and immune niches. Important clues from works in mouse have paved the way to investigate the role of low O2 levels in hematopoiesis. However, whether hypoxia impacts the initial steps
Sara Chabi, Benjamin Uzan, Irina Naguibneva, Julien Rucci, Lucine Fahy, Julien Calvo, Marie-Laure Arcangeli, Frédéric Mazurier, Françoise Pflumio, Rima Haddad   +9 more
doaj  

Hypoxia Induced Downregulation of Na+/H+ Exchanger-1 Activity Decreases Tumor Cell Proliferation

Ankara Üniversitesi Tıp Fakültesi Mecmuas
Objectives: Hypoxia and acidosis are the hallmarks of proliferative tumor microenvironment which can modulate the expression and function of Na+/H+ exchanger-1 (NHE1) via hypoxia inducible factor 1 (Hif).
Gül Şimşek, Hilmi Burak Kandilci
doaj   +1 more source

Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy

Advanced Functional Materials, EarlyView.
Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi, Elias Huber, Leonie Karr, Johnny Tong, Andreas Richard Bausch, Friedrich Christian Simmel, Karen Alim   +6 more
wiley   +1 more source

Mesenchymal stem cell‑derived extracellular vesicles prevent neural stem cell hypoxia injury via promoting miR‑210‑3p expression. [PDF]

Mol Med Rep, 2020
Li F, Zhang J, Liao R, Duan Y, Tao L, Xu Y, Chen A.   +6 more
europepmc   +1 more source

Reversible shutdown of replicon initiation by transient hypoxia in Ehrlich ascites cells [PDF]

, 1992
Hans‐Jörg Riedinger, Volker Gekeler, Hans Christian Probst   +2 more
openalex   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Hypoxia amplifies arecoline-induced invasion and metastasis in oral squamous cell carcinoma – Insights into TGF-β1 signaling and collagen production

Journal of Dental Sciences
Background/Purpose: Betel quid chewing is a major risk factor for oral squamous cell carcinoma (OSCC), largely due to arecoline, a key alkaloid. Hypoxia, common in the tumor microenvironment, also influences cancer progression.
Feng-Cheng Wu, Chun-Chan Ting, Jiiang-Huei Jeng, Hangshen Chen, Yong-Deok Kim, Chia-Chen Wu, Yu-Hsun Kao, Chih-Huang Tseng, Yuk-Kwan Chen, Toru Ogasawara, Kazuto Hoshi, Wen-liang Lo, Tetsu Takahashi, Yi-Hsin Yang, Edward Chengchuan Ko   +14 more
doaj  

Effects of hypoxia and metabolic inhibitors on production of prostacyclin and endothelium‐derived relaxing factor by pig aortic endothelial cells [PDF]

, 1991
Joanna M. Richards, Ian F. Gibson, William Martin   +2 more
openalex   +1 more source

Metal Nanoclusters for Cancer Imaging and Treatment

Advanced Functional Materials, EarlyView.
This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu, Ziping Wang, Qiaofeng Yao, Ping Zhang, Jianping Xie, Xun Yuan   +5 more
wiley   +1 more source

The regulation of cell metabolism by hypoxia and hypercapnia

Journal of Biological Chemistry
Every cell in the body is exposed to a certain level of CO2 and O2. Hypercapnia and hypoxia elicit stress signals to influence cellular metabolism and function. Both conditions exert profound yet distinct effects on metabolic pathways and mitochondrial dynamics, highlighting the need for cells to adapt to changes in the gaseous microenvironment.
Reddan, Ben, Cummins, Eoin P.
openaire   +2 more sources