Results 121 to 130 of about 11,093,569 (425)
Functional Magnetic Resonance Imaging Changes and Increased Muscle Pressure in Fibromyalgia: Insights from Prominent Theories of Pain and Muscle Imaging [PDF]
arXiv, 2023 Fibromyalgia is a complicated and multifaceted disorder marked by widespread chronic pain, fatigue, and muscle tenderness. Current explanations for the pathophysiology of this condition include the Central Sensitization Theory, Cytokine Inflammation Theory, Muscle Hypoxia, Muscle Tender Point Theory, and Small Fiber Neuropathy Theory.
arxiv
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Role of glycosylation in hypoxia-driven cell migration and invasion
Cell Adhesion & Migration, 2019 Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated α-subunit.
Cecilia Arriagada +2 more
doaj +1 more source
Chronic Diseases and Translational Medicine, 2022 Background As erythropoietin (EPO) has been used to treat anemia in cancer patients, negative controversy has continued. Unfortunately, its effects on non‐small‐cell lung carcinoma (NSCLC) cell lines are uncertain and the phenomenon of inducing immune ...
Yajing Zhang, Yangchun Feng, Xiaojie Sun
doaj +1 more source
Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature [PDF]
, 1997 Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. Hypoxia has profound effects on blood vessel tone.
Christou, Helen +3 more
core +1 more source
Hypoxia: Are stem cells in it for the long run? [PDF]
Cell Cycle, 2011 Adult stem cells must persist throughout life to ensure continuous replenishment of dead or damaged cells in various tissues of the body. While numerous studies have already begun to identify some of the factors and mechanisms that regulate long term function and survival of stem cells, there is still much to learn in this regard.
Philip Davy, Richard C. Allsopp
openaire +3 more sources
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Hypoxia-ischemia and retinal ganglion cell damage
Clinical Ophthalmology, 2008 Charanjit Kaur1, Wallace S Foulds2, Eng-Ang Ling11Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 2Singapore Eye Research Institute, SingaporeAbstract: Retinal hypoxia is the potentially blinding ...
Charanjit Kaur +2 more
doaj
Stem Cells International, 2022 Hypoxia-mimetic agents are new potential tools in MSC priming instead of hypoxia incubators or chambers. Several pharmaceutical/chemical hypoxia-mimetic agents can be used to induce hypoxia in the tissues: deferoxamine (DFO), dimethyloxaloylglycine (DMOG)
Agata Nowak-Stępniowska +3 more
doaj +1 more source
Using systemic modeling and Bayesian calibration to investigate the role of the tumor microenvironment on chemoresistance [PDF]
arXiv, 2023 Using a novel modeling approach based on the so-called environmental stress level (ESL), we develop a mathematical model to describe systematically the collective influence of oxygen concentration and stiffness of the extracellular matrix on the response of tumor cells to a combined chemotherapeutic treatment.
arxiv