Results 141 to 150 of about 11,093,569 (425)
Advanced ScienceAlthough hypoxia is known to be associated with immune resistance, the adaptability to hypoxia by different cell populations in the tumor microenvironment and the underlying mechanisms remain elusive.
Zhenzhen Xun +12 more
doaj +1 more source
Cell-line dependent effects of hypoxia prior to irradiation in squamous cell carcinoma lines
Clinical and Translational Radiation Oncology, 2017 Purpose: To assess the impact of hypoxia exposure on cellular radiation sensitivity and survival of tumor cells with diverse intrinsic radiation sensitivity under normoxic conditions. Materials and methods: Three squamous cell carcinoma (SCC) cell lines,
Franziska Hauth +3 more
doaj +1 more source
Modeling the dynamics of hypoxia inducible factor-1α (HIF-1α) within single cells and 3D cell culture systems [PDF]
arXiv, 2014 HIF (Hypoxia Inducible Factor) is an oxygen-regulated transcription factor that mediates the intracellular response to hypoxia in human cells. There is increasing evidence that cell signaling pathways encode temporal information, and thus cell fate may be determined by the dynamics of protein levels.
arxiv
PAKing up to the endothelium [PDF]
, 2009 Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be engaged in neo-vascularization in response to physiological stimuli, such as hypoxia, wound healing ...
arxiv +1 more source
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]
, 2016 The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J. +3 more
core +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
The impact of hypoxia on B cells in COVID-19
EBioMedicine, 2022 Summary: Background: Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2.
Prasanti Kotagiri +21 more
doaj
A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]
, 2001 Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren +4 more
core +1 more source
Regulation of cell proliferation by hypoxia-inducible factors.
American Journal of Physiology - Cell Physiology, 2015 Hypoxia is a physiological cue that impacts diverse physiological processes, including energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis.
Maimon E Hubbi, G. Semenza
semanticscholar +1 more source
Responses of glomus cells to hypoxia and acidosis
The Journal of Physiology, 2013 I read with interest the publication by Lu et al. (2013) in which the authors claim to have found evidence for uncoupling and reciprocity in the responses of carotid body glomus cells to hypoxic and acidic stimuli. By measuring changes in intracellular calcium as an index of chemosensitivity, the authors argue that cells that are highly sensitive to ...
openaire +5 more sources